Pathological pain is a debilitating condition and one of the most frequent reasons patients seek medical care. Pain can be categorized as chronic inflammatory (for example, osteoarthritis, rheumatoid arthritis, gout), neuropathic (including diabetic neuropathy, neuropathy induced by chemotherapy, nervous injury, postherpetic neuralgia, multiple sclerosis) nociplastic (such as fibromyalgia, irritable bowel syndrome or chronic temporomandibular pain disorders) and cancer pain. The efficacy of clinically available analgesics to treat these conditions is still not entirely satisfactory, and relevant bothersome side effects limit their use.
In this sense, studies aiming to advance the management of different pathological pains are critically necessary, such as understanding their pathophysiological mechanisms, discovering new molecules with natural or synthetic analgesic potential, and repositioning drugs with analgesic purposes. Advances in these areas are essential to alleviate painful symptoms and promote a better quality of life for patients who experience chronic pathological pain.
This Research Topic aims to compile articles that address pharmacological advances to treat chronic pathological pain. Different studies are welcome, including reviews and original preclinical and clinical research manuscripts on the following themes:
- Mechanisms involved in the inflammatory, neuropathic, or nociplastic pain
- Pathophysiology of cancer pain
- New molecules, natural or synthetic, with analgesic potential
- Repositioning drugs with analgesic purposes
Pathological pain is a debilitating condition and one of the most frequent reasons patients seek medical care. Pain can be categorized as chronic inflammatory (for example, osteoarthritis, rheumatoid arthritis, gout), neuropathic (including diabetic neuropathy, neuropathy induced by chemotherapy, nervous injury, postherpetic neuralgia, multiple sclerosis) nociplastic (such as fibromyalgia, irritable bowel syndrome or chronic temporomandibular pain disorders) and cancer pain. The efficacy of clinically available analgesics to treat these conditions is still not entirely satisfactory, and relevant bothersome side effects limit their use.
In this sense, studies aiming to advance the management of different pathological pains are critically necessary, such as understanding their pathophysiological mechanisms, discovering new molecules with natural or synthetic analgesic potential, and repositioning drugs with analgesic purposes. Advances in these areas are essential to alleviate painful symptoms and promote a better quality of life for patients who experience chronic pathological pain.
This Research Topic aims to compile articles that address pharmacological advances to treat chronic pathological pain. Different studies are welcome, including reviews and original preclinical and clinical research manuscripts on the following themes:
- Mechanisms involved in the inflammatory, neuropathic, or nociplastic pain
- Pathophysiology of cancer pain
- New molecules, natural or synthetic, with analgesic potential
- Repositioning drugs with analgesic purposes
