Exploring Drug Development With Single Cell Omics Analytics and Stem Cell-Based Disease Models

About this Research Topic

Background

In the ever-evolving landscape of biological research, a remarkable transformation has unfolded, radically altering our approach to understanding cell biology, developmental processes, and the complexities of disease conditions. At the forefront of this revolution stand two groundbreaking technologies: single-cell omics-sequencing-based analytics including single-cell multiomics; and stem cell-based approaches. These pioneering methods have unleashed a profound wave of discoveries, propelling us into a new era of scientific exploration.

The journey into the cellular universe begins with the fundamental role of stem cells. These remarkable entities, with their unique ability to self-renew and multipotentiality, play a pivotal role in the maintenance of tissue homeostasis and the extraordinary process of regeneration. Understanding their dynamics and functions has opened new avenues for therapeutic interventions and regenerative medicine, offering hope to countless disease-suffering individuals around the world.

Furthermore, it is more intriguing to see the remarkable reprogramming of somatic cells into pluripotent stem cells. This transformative process, which can mimic a wide array of disease models when somatic cells are derived from patients or engineered based on genes associated with specific pathophysiological disorders, has the potential to revolutionize our understanding of disease mechanisms and accelerate the development of innovative therapies. The intersection of stem cells biology and disease modeling is a fertile ground for exploration, offering insights that were once considered the stuff of science fiction.

Moreover, these advances have not remained confined to the laboratory alone. The application of single-cell omics analytics and stem cell-based technologies extend their reach to drug screening and development. The amazing ability of stem cell-based models to mimic human disease and the power to precisely interrogate cellular processes at the single-cell level have led to the creation of cutting-edge platforms for the identification and validation of potential drug candidates. This paradigm shift is instrumental in expediting the drug discovery pipeline, offering a glimmer of hope in our relentless pursuit of effective treatment for a multitude of diseases.

It is this extraordinary context that we invite scholars, scientists, and researchers from diverse disciplines to contribute your views and ideas to this compendium (Research Topic). We call for papers that delve into the realms of scRNA-seq and sc-Multiomics analyses, as well as those that explore the profound influence of stem cell-based technologies on disease modeling and drug discovery. This anthology aims to be a comprehensive repository of knowledge, a testament to the remarkable achievement of our scientific community, and a guidepost for future exploration.

As we embark on this journey, we must acknowledge the incredible synergy of these diverse fields and the immense potential they hold. Together, we are poised to unlock the mysteries of cellular biology and diseases that have long confounded us. With this collection of reviews and prospective visions, we aspire to bridge the gap between innovation and application, bringing us closer to the realization of new therapeutic solutions and improved patient outcomes.

Keywords: Single-Cell, Multi-omics, Drug Discovery, Drug Candidates, Drug Screening, Stem-Cell Models

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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