About this Research Topic
Microbial infection promotes cancer development by mediating inflammation and DNA damage. Viruses such as Hepatitis B virus, Hepatitis C virus, Epstein Barr virus, and Human papillomavirus are reported with several human cancers such as liver cancer, Burkitt's lymphoma, and cervical cancer. Bacteria such as Helicobacter pylori are linked with gastric cancer (GC) and colorectal cancer (CRC). Other bacteria are also reported with cancer such as Chlamydia trachomatis, Streptococcus bovis, and Clostridium species are reported with ovarian cancer, CRC, and prostate cancer. Besides, dysbiosis of microbiota is a risk factor for cancer, especially Parasites such as Fusobacterium nucleatum, Bacteroides fragilis, and E.coli.
Still, the area of the microbe linked to cancer development is not fully understood. Besides, genetic, epigenetic factors, microbial factors, and environmental factors affect cancer development. The interaction between one or more of the previously mentioned factors affects cancer initiation and/or progression. The pathogenesis of the cancer-causing microbes and/or microbiota requires more research to identify all the possible pathways linked to cancer. Although inflammation, DNA mutations, and gut leakiness could be common factors reported, other pathways are not known. Besides, the impact of co-infection of one or more pathogens on cancer development is not known. The interaction of environmental toxicants such as smoking and microbes in cancer development is a new area of research. Understanding the microbial pathways helps in the identification of preventive strategies. Agents that inhibit microbial pathogenesis could have potential anticancer effects such as antibiotics, antiviral agents, metabolites from the diet (nutritional supplement), probiotics, prebiotics, oncolytic agents, and vaccines.
Manuscripts including original research articles, or review articles that include the role of microbes in cancer development, microbial pathways, and pathogenesis during cancers, the effect of co-infection between two microbes (either two bacteria, bacteria/ virus, bacteria/ fungi, bacteria/ parasite) on cancer development, the interaction between microbes and genetic or environmental toxicant on cancer, and antimicrobial agents, diet or nutritional supplements that can reduce or inhibit the risk of cancer, are welcome.
Still, the area of the microbe linked to cancer development is not fully understood. Besides, genetic, epigenetic factors, microbial factors, and environmental factors affect cancer development. The interaction between one or more of the previously mentioned factors affects cancer initiation and/or progression. The pathogenesis of the cancer-causing microbes and/or microbiota requires more research to identify all the possible pathways linked to cancer. Although inflammation, DNA mutations, and gut leakiness could be common factors reported, other pathways are not known. Besides, the impact of co-infection of one or more pathogens on cancer development is not known. The interaction of environmental toxicants such as smoking and microbes in cancer development is a new area of research. Understanding the microbial pathways helps in the identification of preventive strategies. Agents that inhibit microbial pathogenesis could have potential anticancer effects such as antibiotics, antiviral agents, metabolites from the diet (nutritional supplement), probiotics, prebiotics, oncolytic agents, and vaccines.
Manuscripts including original research articles, or review articles that include the role of microbes in cancer development, microbial pathways, and pathogenesis during cancers, the effect of co-infection between two microbes (either two bacteria, bacteria/ virus, bacteria/ fungi, bacteria/ parasite) on cancer development, the interaction between microbes and genetic or environmental toxicant on cancer, and antimicrobial agents, diet or nutritional supplements that can reduce or inhibit the risk of cancer, are welcome.
Keywords: Microbe, Infection, Inflammatory response, Pathogenesis, Cancer, Therapy, microbial pathway, cancer progression
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