About this Research Topic
Dendritic cells (DCs) constitute a heterogeneous and complex population of antigen-presenting cells (APCs). These cells specialize in antigen capture and processing, which are then presented to presentation to immunocompetent T cells. However, DCs, go beyond their role in antigen presentation and exhibit a wide range of immunological functions. Based on their biological role and tissue location, they can be categorized into distinct subsets, primarily into myeloid and plasmacytoid cells. Our understanding of DC diversity continues to expand as a result of extensive research. These cells orchestrate the immune response, by bridging the gap between the innate and adaptive immune response. Thus, they can significantly affect the immune reactions, becoming either a friend or a foe.
Any alteration in the activity or subpopulation distributions of DC may have a profound impact on the function of the immune system, potentially resulting in various disorders. Consequently, they have emerged as an attractive target for therapeutic intervention. Despite their critical roles, DCs as APCs have often been underappreciated. However, their perception has changed over in recent years and DCs have attracted more scientific attention highlighting their biological importance. The discovery of new DC subtypes uncovered new immunological aspects and plausible therapeutic options. The main goal of this research topic is to provide a forum for scientists dedicated to the study of dendritic cells, to give the opportunity to share knowledge and experience, to inspire and motivate each other, and to create a scientific community.
Therefore, in this Research Topic, we welcome the submission of original research and review articles that cover a wide array of sub-topics, including but not limited to the following:
- Dendritic cell biology, including phenotypes, functionalities, molecular and epigenetic characteristics.
- Alternations in dendritic cell subpopulations in diseases of various origin, including autoimmunity, inflammatory diseases, cancer, infections
- Exploring DCs as potential targets for innovative therapeutic strategies
- Investigating the role of DCs in transplantation
- DCs-based immunotherapy and the application of autologous DC in cancer treatment
- DCs-based vaccines in drug-resistant infections
- Immunomodulatory potential of DCs
- Diverse models for DC research
We look forward to receiving contributions that advance our understanding of these crucial aspects of dendritic cell research.
Any alteration in the activity or subpopulation distributions of DC may have a profound impact on the function of the immune system, potentially resulting in various disorders. Consequently, they have emerged as an attractive target for therapeutic intervention. Despite their critical roles, DCs as APCs have often been underappreciated. However, their perception has changed over in recent years and DCs have attracted more scientific attention highlighting their biological importance. The discovery of new DC subtypes uncovered new immunological aspects and plausible therapeutic options. The main goal of this research topic is to provide a forum for scientists dedicated to the study of dendritic cells, to give the opportunity to share knowledge and experience, to inspire and motivate each other, and to create a scientific community.
Therefore, in this Research Topic, we welcome the submission of original research and review articles that cover a wide array of sub-topics, including but not limited to the following:
- Dendritic cell biology, including phenotypes, functionalities, molecular and epigenetic characteristics.
- Alternations in dendritic cell subpopulations in diseases of various origin, including autoimmunity, inflammatory diseases, cancer, infections
- Exploring DCs as potential targets for innovative therapeutic strategies
- Investigating the role of DCs in transplantation
- DCs-based immunotherapy and the application of autologous DC in cancer treatment
- DCs-based vaccines in drug-resistant infections
- Immunomodulatory potential of DCs
- Diverse models for DC research
We look forward to receiving contributions that advance our understanding of these crucial aspects of dendritic cell research.
Keywords: Dendritic cells, autoimmune disease, cancer, vaccine, therapy, immunomodulation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
