About this Research Topic
Human Immunodeficiency Virus (HIV) severely damages the immune system, with T-lymphocytes being the primary targets. Although antiretroviral therapy (ART) is effective in treating HIV infection, the virus may remain in reservoirs and cause persistent infection, leading to cumulative deleterious effects on immune function. It is believed that the persistent reservoir of latent HIV is the major barrier to HIV eradication. More research is needed on the structure, replication, persistence, and latency of HIV itself, as well as the characteristics of the host immune response, including the role of naive CD4+ T cells, stem cell-like memory T cells, central memory T cells, transitional memory T cells, effector memory T cells, T helper 1, 2, 17, 9 (Th1, Th2, Th17, Th9) cells, regulatory T cells (Treg), follicular T helper cells (Tfh), astrocytes, dendritic cells, and macrophages. This is crucial for characterizing both virological and immunological mechanisms associated with HIV/AIDS pathogenesis, and enables us to identify key factors during viral host interaction, facilitating the development of novel vaccines and other therapeutic strategies.
We invite investigators from all around the world to contribute original research articles as well as review articles that will contribute to ongoing efforts for the elimination of HIV/AIDS.
Specifically, manuscripts focusing on the following subtopics are highly welcome.
1. Dynamics of the HIV-1 virus, including evolution, mutation and adaptation
2. Structure of HIV-1 proteins, focusing on potential targets for vaccine design
3. Replication of HIV-1 virus
4. The mechanism of HIV-1 persistence and latency
5. Interplay between virus and host
6. Role of different immune cells, including T cells, B cells, astrocytes, dendritic cells, macrophages, etc
7. The mechanisms of HIV-1 infection spread among T cells in tissues
8. The mechanisms of ongoing inflammation and immune activation and the impact
9. Advances in vaccine strategies, in terms of targets, delivery systems, and devices
10. New tools and platform technologies for vaccine development
We invite investigators from all around the world to contribute original research articles as well as review articles that will contribute to ongoing efforts for the elimination of HIV/AIDS.
Specifically, manuscripts focusing on the following subtopics are highly welcome.
1. Dynamics of the HIV-1 virus, including evolution, mutation and adaptation
2. Structure of HIV-1 proteins, focusing on potential targets for vaccine design
3. Replication of HIV-1 virus
4. The mechanism of HIV-1 persistence and latency
5. Interplay between virus and host
6. Role of different immune cells, including T cells, B cells, astrocytes, dendritic cells, macrophages, etc
7. The mechanisms of HIV-1 infection spread among T cells in tissues
8. The mechanisms of ongoing inflammation and immune activation and the impact
9. Advances in vaccine strategies, in terms of targets, delivery systems, and devices
10. New tools and platform technologies for vaccine development
Keywords: replication, latency, immune response, vaccine development strategies, persistent infection
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
