Myeloid cells play crucial roles in both innate and adaptive immunity. They serve various pro- and anti-inflammatory functions in different immune responses. When pathogens or tumors invade the body, myeloid cells act as 'sentinels' for the immune system. They detect and process bacteria, viruses, and tumors, mounting a defense against these invaders. After the initial processing, myeloid cells release cytokines and chemokines to attract more innate or adaptive immune cells to the site of inflammation. This helps the body quickly eliminate external threats.
In a healthy immune system, myeloid cells efficiently utilize metabolites like glucose, fatty acids, and amino acids to generate energy for combating pathogens. However, in cases of metabolic dysfunction, myeloid cells may suffer from energy production deficits and become overwhelmed with glucose, lipids, and proteins. This can lead to cell apoptosis and necrosis at the inflammation site, elevating the risk of infectious diseases, tumor development, as well as chronic conditions such as atherosclerosis, diabetes, obesity, and Alzheimer's.
Within this Research Topic, we invite experts and researchers to explore the fascinating area of myeloid cell metabolism across diverse disease models. Our goal is to investigate the potential for enhancing myeloid cell metabolism and elucidate the underlying mechanistic pathways responsible for these enhancements.
We welcome contributions from basic, translational, computational, and applied research focusing on the functions of myeloid cell metabolism in innate and adaptive immune responses. Submissions of different article types to this Research Topic are welcome, especially Reviews, Mini-Reviews, Original Research papers, and Brief Reports. Potential areas of interest may include, but are not limited to:
1. Examining myeloid cell metabolic functions in infection, tumor, and chronic disease models.
2. The influence of metabolite preferences on myeloid cell function across different diseases.
3. Exploring metabolism-related pathways in myeloid cells.
4. Unraveling the relationship between metabolism and antigen presentation in myeloid cells.
5. Investigating the role of myeloid ACE in enhancing myeloid cell metabolism and its impact on infections, tumors, and chronic diseases, including atherosclerosis, diabetes, obesity, and Alzheimer's.
6. Elucidating the mechanisms underlying enhanced metabolic functions in myeloid cells in infection, tumor, and chronic disease models.
Myeloid cells play crucial roles in both innate and adaptive immunity. They serve various pro- and anti-inflammatory functions in different immune responses. When pathogens or tumors invade the body, myeloid cells act as 'sentinels' for the immune system. They detect and process bacteria, viruses, and tumors, mounting a defense against these invaders. After the initial processing, myeloid cells release cytokines and chemokines to attract more innate or adaptive immune cells to the site of inflammation. This helps the body quickly eliminate external threats.
In a healthy immune system, myeloid cells efficiently utilize metabolites like glucose, fatty acids, and amino acids to generate energy for combating pathogens. However, in cases of metabolic dysfunction, myeloid cells may suffer from energy production deficits and become overwhelmed with glucose, lipids, and proteins. This can lead to cell apoptosis and necrosis at the inflammation site, elevating the risk of infectious diseases, tumor development, as well as chronic conditions such as atherosclerosis, diabetes, obesity, and Alzheimer's.
Within this Research Topic, we invite experts and researchers to explore the fascinating area of myeloid cell metabolism across diverse disease models. Our goal is to investigate the potential for enhancing myeloid cell metabolism and elucidate the underlying mechanistic pathways responsible for these enhancements.
We welcome contributions from basic, translational, computational, and applied research focusing on the functions of myeloid cell metabolism in innate and adaptive immune responses. Submissions of different article types to this Research Topic are welcome, especially Reviews, Mini-Reviews, Original Research papers, and Brief Reports. Potential areas of interest may include, but are not limited to:
1. Examining myeloid cell metabolic functions in infection, tumor, and chronic disease models.
2. The influence of metabolite preferences on myeloid cell function across different diseases.
3. Exploring metabolism-related pathways in myeloid cells.
4. Unraveling the relationship between metabolism and antigen presentation in myeloid cells.
5. Investigating the role of myeloid ACE in enhancing myeloid cell metabolism and its impact on infections, tumors, and chronic diseases, including atherosclerosis, diabetes, obesity, and Alzheimer's.
6. Elucidating the mechanisms underlying enhanced metabolic functions in myeloid cells in infection, tumor, and chronic disease models.
