The Role of Inflammation and Immune Control in Digestive Disease and Therapeutic Approaches

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Background

Digestive system diseases, including gastroenteritis, irritable bowel syndrome, Crohn's disease, ulcerative colitis, hepatitis, and pancreatitis, present as a common disease that affects millions of people worldwide. The pathogenesis of these diseases remains as a complex context, involving multiple factors such as genetics, environment, lifestyle, microbiome, and immune system. Recently, multi-omics analysis strategies raised much concern about the proximal and distal cross-talks between immunocytes and tissue-specific cell types. Methods for the diagnosis, treatment, and prognosis of digestive diseases related to immunity, such as stem cell therapies, small-molecule chemical drugs, biologics, and phytochemicals, have been successively developed and applied. However, the specific functions and related mechanisms of immune cells, such as T cells, B cells, macrophages, and other immune cells in digestive diseases, still need further exploration. Thus, investigating the potential and promising immunomodulatory targets would help us uncover the initiation and development of molecular events of immune disorders in digestive system diseases, which in turn would promote their prevention and treatment.

The goal of this Research Topic is to provide a forum to advance research on the comprehensive understanding of immune regulatory mechanisms and the role of abnormal mechanisms in the occurrence and development of digestive diseases, as well as to explore innovative immune-oriented drugs or treatment interventions in the attempt to achieve a beneficial impact on the diagnosis, prevention, therapy, and prognosis of digestive diseases.

Bullet points are as below:
1) The specific functions and clinical significance of immune cells (e.g., T cells, B cells, macrophages, and other immune cells, etc.) in digestive diseases
2) The mechanism of immune cells participate in inflammatory reactions and tissue damage in digestive diseases
3) The mechanism of regulators affecting the inflammatory response of the digestive system (e.g., nuclear receptor/membrane receptor pathway, etc.)
4) The role of small molecules in digestive diseases (e.g., cytokines, chemical factors, anti-inflammatory agents, immune regulatory molecules, etc.)
5) Development of novel anti-inflammatory and immunomodulatory drugs for digestive diseases

Bibliometric studies are outside of the scope of this section and may be rejected or redirected to other journals/sections as appropriate.
Bioinformatics or Computational Analysis of public genome or transcriptome databases need to be accompanied by robust and relevant validation to be submitted to this section.
Manuscripts describing the pharmacological action of drugs used in traditional medicine in models of disease, such as inflammatory disease, are not in scope unless they have a strong focus on the immune system.

Keywords: Digestive Disease

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