Molecular Mechanisms Underlying Exercise-Alleviated Sarcopenic Obesity

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Background

Sarcopenic obesity, characterized by the concurrent decline in muscle mass and function alongside an increase in body fat, has emerged as a pressing health concern, particularly in the context of accelerated aging. This multifaceted condition encompasses intricate metabolic, physiological, and molecular alterations that collectively elevate the risk of age-related diseases and contribute to an overall decline in well-being. A comprehensive understanding of the intricate molecular mechanisms that underlie the interplay between sarcopenic obesity and accelerated aging is imperative for the development of precise and effective interventions.

Within this complex scenario, nutrition and physical activity have been recognized as pivotal determinants to ameliorate the consequences of sarcopenic obesity. Specifically, both interventions exert profound influences on muscle metabolism, adipose tissue function, and overall health outcomes. Exercise, in particular, plays an essential role in modulating these physiological processes. The molecular underpinnings of how exercise influences sarcopenic obesity and the aging process are subjects of paramount importance.

An understanding of these molecular mechanisms is indispensable for the formulation of targeted strategies aimed at mitigating the deleterious health consequences associated with sarcopenic obesity and promoting the attainment of healthy aging. As such, exploring the intricate network of molecular interactions that connect exercise, sarcopenic obesity, and accelerated aging represents a critical frontier in biomedical research with far-reaching implications for public health and well-being. With a thorough understanding of the role of exercise in these molecular processes, we can develop innovative interventions that harness the benefits of physical activity to enhance not only musculoskeletal health but also overall longevity and well-being.

The primary objective of this Research Topic is to elucidate the pivotal role of exercise in addressing the pressing issue of sarcopenic obesity and its intricate connection with accelerated aging. Our aim is to delve into recent advancements in the field and systematically unravel the multifaceted molecular pathways that underpin the development and progression of sarcopenic obesity and accelerated aging, with a particular focus on the influence of exercise. In doing so, we seek to comprehensively assess how exercise, alongside nutrition and other environmental factors, impacts these intricate processes.

Through the synthesis of cutting-edge research and the promotion of interdisciplinary collaborations, this Research Topic aspires to significantly advance our understanding of sarcopenic obesity and accelerated aging, with exercise at its core. Ultimately, our overarching goal is to lay the groundwork for the development of effective interventions and the creation of personalized, evidence-based strategies. These strategies are envisioned to not only mitigate the adverse health consequences associated with sarcopenic obesity but also to enhance the overall health and well-being of individuals affected by this complex condition, fostering a healthier aging experience.

We invite submissions of original research papers, meta-analyses, and review articles with a primary focus on the pivotal role of exercise in unraveling the mechanistic insights and molecular signatures of sarcopenic obesity and accelerated aging. In addition, we strongly encourage manuscripts that bridge the gap between fundamental molecular knowledge and innovative medical applications, as well as those reporting on groundbreaking disease biomarkers. The scope of this Research Topic encompasses various aspects related to exercise and its impact on these interconnected processes. Topics of particular interest include, but are not limited to:

1) Elucidating the molecular changes and pathways involved in the pathogenesis and progression of sarcopenic obesity and accelerated aging, with a specific emphasis on the influence of exercise.

2) Investigating the integral role of nutrition and physical activity in shaping the development and progression of sarcopenic obesity and accelerated aging.

3) Exploring the intricate molecular interactions within the aging and obese microenvironments, encompassing immune cell interactions, adipose tissue crosstalk, and microbiota influences, with a focus on how exercise modulates these dynamics.

4) Identifying and validating molecular biomarkers that can facilitate the diagnosis, prognosis, and stratification of individuals affected by sarcopenic obesity and accelerated aging, emphasizing the role of exercise in their assessment.

5) Examining genomic profiling and epigenetic modifications associated with sarcopenic obesity and accelerated aging, emphasizing how exercise can influence these genetic and epigenetic factors.

6) Highlighting preclinical research endeavors that investigate molecular-based therapies and interventions for sarcopenic obesity and accelerated aging, with a particular emphasis on the role of exercise as a potential therapeutic strategy.

By focusing on the critical nexus of exercise and molecular mechanisms, we aim to promote a deeper understanding of how physical activity can be harnessed as a potent tool in addressing the complex challenges posed by sarcopenic obesity and accelerated aging, ultimately advancing both scientific knowledge and clinical applications in this vital area of research.

Keywords: Epigenetics, Exercise, Inflammaging, Nutrition, Obesity, Senescence, Sarcopenia, Telomere length

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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