About this Research Topic
A neurotropic virus is a type of virus that has a strong affinity for infecting neurons, which are the primary cells of the nervous system responsible for transmitting signals. These viruses are specialized in targeting and entering neurons, often leading to neurological symptoms and eventual disability that severely impact patients' quality of life.
Neurotropic viruses have evolved specific molecular mechanisms that allow them to exploit the unique characteristics of neurons for their replication and spread. They can enter neurons, replicate within them, and potentially move between neurons, either within a single host or through transmission to new hosts.
Exemplary instances of neurotropic viruses encompass herpesviruses, the La Crosse virus, rabies virus, poliovirus, Japanese encephalitis virus, Theiler's encephalomyelitis virus, Zika virus, among others. The replication and dissemination patterns of these viruses within neural enclaves are contingent upon the virus type in question, as well as its intricate interactions with the neural milieu. The dynamics of virus proliferation and dissemination amidst and between neurons encompass multifarious phases, encompassing viral ingress, intracellular replication, axonal transport, instances of latency, and neuron-to-neuron transmission.
Understanding the intricacies of virus replication and spread within neurons is crucial for developing strategies to prevent or treat neurological infections. Ongoing research in this field aims to elucidate these mechanisms and develop targeted interventions to mitigate the impact of viral infections on the nervous system. Identifying the mechanisms of virus replication and spreading within and between neurons that may help guide development of novel antiviral strategies.
This research topic welcomes, but is not limited to submissions including original research, review, mini-review, opinion, perspective, and methods on the following areas:
Neurotropic virus replication and spread within and between neurons
Intracellular replication processes
Axonal transport and inter-neuronal propagation
Viral Latency
Modes of neuron-to-neuron transmission
Novel and emerging neurotropic viruses
Unique challenges of antiviral modalities against neurotropic viruses
Neurotropic viruses have evolved specific molecular mechanisms that allow them to exploit the unique characteristics of neurons for their replication and spread. They can enter neurons, replicate within them, and potentially move between neurons, either within a single host or through transmission to new hosts.
Exemplary instances of neurotropic viruses encompass herpesviruses, the La Crosse virus, rabies virus, poliovirus, Japanese encephalitis virus, Theiler's encephalomyelitis virus, Zika virus, among others. The replication and dissemination patterns of these viruses within neural enclaves are contingent upon the virus type in question, as well as its intricate interactions with the neural milieu. The dynamics of virus proliferation and dissemination amidst and between neurons encompass multifarious phases, encompassing viral ingress, intracellular replication, axonal transport, instances of latency, and neuron-to-neuron transmission.
Understanding the intricacies of virus replication and spread within neurons is crucial for developing strategies to prevent or treat neurological infections. Ongoing research in this field aims to elucidate these mechanisms and develop targeted interventions to mitigate the impact of viral infections on the nervous system. Identifying the mechanisms of virus replication and spreading within and between neurons that may help guide development of novel antiviral strategies.
This research topic welcomes, but is not limited to submissions including original research, review, mini-review, opinion, perspective, and methods on the following areas:
Neurotropic virus replication and spread within and between neurons
Intracellular replication processes
Axonal transport and inter-neuronal propagation
Viral Latency
Modes of neuron-to-neuron transmission
Novel and emerging neurotropic viruses
Unique challenges of antiviral modalities against neurotropic viruses
Keywords: Neurotropic viruses, Virus Replication, Neurons
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