Organ crosstalk is a complicated two-way biological communication that occurs between distal organs and is mediated through cellular, soluble, and neurohormonal processes. An appreciation of the importance of organ crosstalk in critical illness is growing, however, there is still insufficient understanding to effectively subvert clinical issues. Future studies are required to better understand the pathophysiological pathways of organ crosstalk, thus reducing the progression toward multiorgan dysfunction in critically ill patients.
Of particular importance is the presence of lung disorders can affect brain, heart, and kidney functions, as well as malfunction of such organs can affect lung physiology. As an example, mechanical ventilation can be associated with new complications in distal organs. The use of positive end-expiratory pressure to the lung is a well-known factor that can affect the function of distal organs through several pathophysiological mechanisms. Also, lung damage and therapy can activate an immune-inflammatory reaction with systemic response and possible detrimental effects on distal organs.
The current Research Topic aims to publish original research, mini-reviews, reviews, data reports, opinions, protocols, and perspectives on the Research Topic "Crosstalk between the lung and brain, heart, kidney and vascular system in critical illness". Particularly, we encourage submission of articles focusing on the interaction between lung physiology and therapies, including mechanical ventilation, and their effects on brain, heart, kidney and vascular system. Also, the interaction between brain, heart, and kidney disease with lung function and recovery.
The following themes will be discussed:
- lung and distal organ interaction (kidney, heart, brain, vascular system, skeletal muscle)
- crosstalk between different organs (lung, kidney, heart, brain, vascular system, skeletal muscle)
- lung damage as a consequence of other organ injury (kidney, heart, brain)
- distal organ damage after lung injury (kidney, heart, brain)
- effects of different settings of mechanical ventilation on distal organs (kidney, heart, brain, vascular system)
Organ crosstalk is a complicated two-way biological communication that occurs between distal organs and is mediated through cellular, soluble, and neurohormonal processes. An appreciation of the importance of organ crosstalk in critical illness is growing, however, there is still insufficient understanding to effectively subvert clinical issues. Future studies are required to better understand the pathophysiological pathways of organ crosstalk, thus reducing the progression toward multiorgan dysfunction in critically ill patients.
Of particular importance is the presence of lung disorders can affect brain, heart, and kidney functions, as well as malfunction of such organs can affect lung physiology. As an example, mechanical ventilation can be associated with new complications in distal organs. The use of positive end-expiratory pressure to the lung is a well-known factor that can affect the function of distal organs through several pathophysiological mechanisms. Also, lung damage and therapy can activate an immune-inflammatory reaction with systemic response and possible detrimental effects on distal organs.
The current Research Topic aims to publish original research, mini-reviews, reviews, data reports, opinions, protocols, and perspectives on the Research Topic "Crosstalk between the lung and brain, heart, kidney and vascular system in critical illness". Particularly, we encourage submission of articles focusing on the interaction between lung physiology and therapies, including mechanical ventilation, and their effects on brain, heart, kidney and vascular system. Also, the interaction between brain, heart, and kidney disease with lung function and recovery.
The following themes will be discussed:
- lung and distal organ interaction (kidney, heart, brain, vascular system, skeletal muscle)
- crosstalk between different organs (lung, kidney, heart, brain, vascular system, skeletal muscle)
- lung damage as a consequence of other organ injury (kidney, heart, brain)
- distal organ damage after lung injury (kidney, heart, brain)
- effects of different settings of mechanical ventilation on distal organs (kidney, heart, brain, vascular system)
