Metabolic Syndrome in Patients with Diabetes: Identification of Biomarkers

Obesity, insulin resistance, dyslipidemia, hypertension, cancer and non-alcoholic fatty liver disease are critical metabolic disorders. They are characterized by an inflammatory state in metabolic tissues and induce endothelial inflammation and activation, which play a critical role in the development of insulin resistance/diabetes, aging and the associated cardiovascular risk. Several studies and treatments are trying to reduce these metabolic syndromes to improve the life quality in all cycles of life. Recently it has been studied that obesity and metabolic disorders are a consequence of a dysfunction of the skeletal muscle mitochondria, by reprogramming the metabolism towards greater synthesis and accumulation of lipids. Mitochondrial dysfunction contributes to the oxidative stress, systemic inflammation, dysregulated production of mitochondria-associated metabolic intermediates, lower energy production and imbalanced redox status. The study of inflammation and mitochondrial biomarkers could therefore be crucial to develop a preventive therapy for MS in patients with diabetes.

The goal of this research topic is to find biomarkers of metabolic disorders in patients with diabetes. This will hopefully provide effective tools to reduce the consequences of diabetes, improving mitochondrial function, quality of life and life expectancy.

This research topic welcomes manuscripts that identify and provide a better understanding of biomarkers involved in the correct functioning of the human body and their involvement in patients with metabolic syndrome and diabetes. This research topic has implications at a clinical, healthcare, economic and social level. It contributes to the prevention and treatment of patients with diabetes who suffer with metabolic disorders.

This Research Topic welcomes original research and review articles.