About this Research Topic
Despite all the advances achieved in the field during recent years, there is no definitive treatment for most of the allergic diseases diagnosed today. Allergen-specific immunotherapy is seen as a promising strategy to solve this problem, but most formulations described up to now do not provide sustained unresponsiveness to the allergen once the treatment is discontinued. Animal models provide a powerful tool to delve into the pathophysiology of allergy, since they replicate clinical features of the disease (e.g., anaphylactic shock in food allergy, impairment of lung function in asthma). Besides, they have successfully been used to test the safety and efficacy of novel treatments (e.g., skin test patches, engineered nanoparticles), directly impacting future research in clinical trials.
This Research Topic aims to provide a comprehensive collection of articles highlighting the importance of animal models in the allergy field, from two different (but complementary) perspectives:
- Basic science: Aiming to provide new knowledge in the molecular mechanisms of allergic sensitization, effector responses (including IgG-mediated allergic reactions) and IgE memory, derived from in vivo studies.
- Preclinical research: Aiming to show the potential of new therapeutic strategies, based on its preclinical performance in animal models.
Authors are encouraged to submit Original Research articles, Short Reports, Reviews and Systematic Reviews, including but not limited to the following topics:
- Underlying molecular and cellular mechanisms of allergic sensitization, derived from in vivo models.
- Novel aspects of allergic memory, including both B and T responses, derived from in vivo models.
- Novel mechanisms of effector cells in allergy, derived from in vivo models.
- Novel aspects of IgG-mediated allergic responses, derived from in vivo models.
- In vivo studies regarding the impact of microbiota and environmental factors in allergy.
- Use of animal models to test new allergy therapeutics.
- New sensitization protocols to allergens currently lacking robust in vivo models.
- Differences among murine strains towards induction of allergic responses.
- Strengths and weaknesses of different animal models towards translation of the results to the clinic.
Conflict of interest declaration: Topic Editor Prof Pål Johansen has received financial and material support from Allergy Therapeutics Ltd., from Bencard AG, from Saiba AG and from PCI Biotech and travel grants to attend conferences from Allergy Therapeutics Ltd. and Bencard AG.
This Research Topic aims to provide a comprehensive collection of articles highlighting the importance of animal models in the allergy field, from two different (but complementary) perspectives:
- Basic science: Aiming to provide new knowledge in the molecular mechanisms of allergic sensitization, effector responses (including IgG-mediated allergic reactions) and IgE memory, derived from in vivo studies.
- Preclinical research: Aiming to show the potential of new therapeutic strategies, based on its preclinical performance in animal models.
Authors are encouraged to submit Original Research articles, Short Reports, Reviews and Systematic Reviews, including but not limited to the following topics:
- Underlying molecular and cellular mechanisms of allergic sensitization, derived from in vivo models.
- Novel aspects of allergic memory, including both B and T responses, derived from in vivo models.
- Novel mechanisms of effector cells in allergy, derived from in vivo models.
- Novel aspects of IgG-mediated allergic responses, derived from in vivo models.
- In vivo studies regarding the impact of microbiota and environmental factors in allergy.
- Use of animal models to test new allergy therapeutics.
- New sensitization protocols to allergens currently lacking robust in vivo models.
- Differences among murine strains towards induction of allergic responses.
- Strengths and weaknesses of different animal models towards translation of the results to the clinic.
Conflict of interest declaration: Topic Editor Prof Pål Johansen has received financial and material support from Allergy Therapeutics Ltd., from Bencard AG, from Saiba AG and from PCI Biotech and travel grants to attend conferences from Allergy Therapeutics Ltd. and Bencard AG.
Keywords: animal models, molecular mechanism, sensitization, immunotherapy, IgE memory, translational research
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
