Clinical Relevance of the Immune-to-Brain and Brain-to-Immune Communications

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Editorial

11 January 2019

Editorial: Clinical Relevance of the Immune-to-Brain and Brain-to-Immune Communications

Julie Lasselin

,

Manfred Schedlowski

,

Mats Lekander

and

Martin Hadamitzky

3,504 views

5 citations

Editors

4

Julie Lasselin

Karolinska Institutet (KI)

Martin Hadamitzky

Essen University Hospital

Manfred Schedlowski

University of Duisburg-Essen

Mats Lekander

Karolinska Institutet (KI)

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Experimental and clinical evidence demonstrates an intense crosstalk among the nervous, endocrine and immune systems. The central nervous system (CNS) not only has the capacity to affect peripheral immune function, but is also able to sense and process signals from the peripheral immune system. The bi-directional interaction between the CNS and the peripheral immune system has gained great interest as it can help better understand disease pathophysiology as well as improving health and treatment outcomes in patients. On the one hand, inflammatory factors are known to affect CNS functions and to induce neuropsychiatric symptoms, making immune-to-brain communication highly relevant for psychiatric diseases and their treatments. On the other hand, analyzing pathways of brain-to-immune communication will help to understand the pathophysiology of chronic inflammatory disorders and will form the basis for optimizing treatment of these diseases.

The potential clinical relevance of the bidirectional communication between the brain and the peripheral immune system is largely disregarded. For this Research Topic, we will therefore encourage researchers to submit original work or perspectives that provide new insights on the clinical relevance of brain-to-immune and immune-to-brain communications.

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Editors

Julie Lasselin

Karolinska Institutet (KI)

Martin Hadamitzky

Essen University Hospital

Manfred Schedlowski

University of Duisburg-Essen

Mats Lekander

Karolinska Institutet (KI)

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111,837 Total views

83,446 Article views

25,116 Article downloads

3,275 Topic views

Published In

Frontiers in Behavioral Neuroscience

Behavioral Neuroscience Archive, Emotion Regulation and Processing, Behavioral Endocrinology, Individual and Social Behaviors, Learning and Memory, Motivation and Reward, Pathological Conditions

Frontiers in Neurology

Multiple Sclerosis and Neuroimmunology

Frontiers in Immunology

Multiple Sclerosis and Neuroimmunology

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