Inflammatory skin diseases are frequent in number and often lead to a decreased quality of life in the affected patients. These diseases result from a complex interplay between the innate and adaptive immune systems. Type 1 inflammation is an immune response driven primarily by Th1 cells, which secrete pro-inflammatory cytokines, notably Interferon-gamma. The initiation of Type 1 inflammation is typically triggered by the recognition of antigens associated with intracellular pathogens. Dendritic cells present these antigens to naive T-cells, leading to the differentiation of predominantly Th1 cells, which in turn activate other immune cells, including macrophages and cytotoxic T-cells. In chronic inflammation, the infiltration of T cells drives the perpetuating cycle of inflammation at the epidermal barrier. Th1-induced inflammation can synergize with recruitment and heightened activity of other T cell subsets such as Th17 cells. Typical type 1 inflammatory skin diseases include psoriasis, lichen planus, acne, hidradenitis suppurativa, pityriasis rubra pilaris, adverse cutaneous drug eruptions, and autoimmune disorders such as vitiligo and lupus erythematodes.The goal of this Research Topic is to help understand the intricate mechanisms through which the innate and adaptive immune systems drive inflammatory skin diseases. This is crucial for the development of targeted therapies, aiming to restore immune homeostasis and ameliorate the burden of these debilitating conditions.This Research Topic aims to encompass translational and basic science work on type 1 inflammatory skin diseases. In particular, the emphasis of the topic is the interplay between the innate and adaptive immune system but a focus on either of these two immune arms is also of significant interest. We are aiming to receive mostly original articles, however, also original review articles are welcome.
Inflammatory skin diseases are frequent in number and often lead to a decreased quality of life in the affected patients. These diseases result from a complex interplay between the innate and adaptive immune systems. Type 1 inflammation is an immune response driven primarily by Th1 cells, which secrete pro-inflammatory cytokines, notably Interferon-gamma. The initiation of Type 1 inflammation is typically triggered by the recognition of antigens associated with intracellular pathogens. Dendritic cells present these antigens to naive T-cells, leading to the differentiation of predominantly Th1 cells, which in turn activate other immune cells, including macrophages and cytotoxic T-cells. In chronic inflammation, the infiltration of T cells drives the perpetuating cycle of inflammation at the epidermal barrier. Th1-induced inflammation can synergize with recruitment and heightened activity of other T cell subsets such as Th17 cells. Typical type 1 inflammatory skin diseases include psoriasis, lichen planus, acne, hidradenitis suppurativa, pityriasis rubra pilaris, adverse cutaneous drug eruptions, and autoimmune disorders such as vitiligo and lupus erythematodes.The goal of this Research Topic is to help understand the intricate mechanisms through which the innate and adaptive immune systems drive inflammatory skin diseases. This is crucial for the development of targeted therapies, aiming to restore immune homeostasis and ameliorate the burden of these debilitating conditions.This Research Topic aims to encompass translational and basic science work on type 1 inflammatory skin diseases. In particular, the emphasis of the topic is the interplay between the innate and adaptive immune system but a focus on either of these two immune arms is also of significant interest. We are aiming to receive mostly original articles, however, also original review articles are welcome.