Collaborative Efforts for Understanding the Human Brain

  • 20k

    Total downloads

  • 119k

    Total views and downloads

Download PDFDownload EPUB

About this Research Topic

Submission closed

Background

The human brain is one of the longest standing mysteries, perplexing people in all corners of the world. Yet the clues to solving this international enigma seem to also be internationally dispersed. New efforts in collaborative neuroscience aim to pool together not just these clues, but also the researchers finding them. Large-scale consortia such as Enhancing Neuro Imaging Genetics through Meta Analysis (ENIGMA), Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE), and others have the ability to pool together inferences from neuroimaging and genetic data from sites worldwide to provide greater statistical power to answer challenging questions. Key contributors to these global efforts are already multisite efforts themselves, such as the Alzheimers Disease Neuroimaging Initiative (ADNI), the Autism Brain Imaging Data Exchange (ABIDE), and 1000 Functional Connectomes, among many others, which are generating vast datasets for rich data-driven discoveries, empowering global efforts and providing critical means for reproducible science.

These national and international efforts have also resulted in an expanding network of scientists and medical professionals who are successfully collaborating to piece together how the brain is altered in cases of disease, how it changes throughout life, and the genetic and environmental factors that promote its well being or pose a risk to brain health. In some cases (e.g., ENIGMA), individual investigators can even contribute to large-scale studies of global trends and effects without ever parting with their data.
While these efforts may be extremely fruitful, new challenges arise when combining data collected across multiple sites in prospective coordinated studies as well as retrospective collaborative efforts.

Effectively combining data across sites requires harmonized protocols, processing streams and workflows comprised of stringent data specifications, image processing steps, rigorous quality control, clinical trait calibration, and standardized statistical tests. The development of these protocols is not trivial, and requires rigorous testing, and retesting, to ensure they are applicable and reproducible across diverse, uniquely collected data and will help answer a variety of questions about the living brain. As imaging and image processing technology advances and new modalities are introduced, an unimaginable number of features are able to be extracted from a single brain imaging session; this parallels the increased breadth of clinical, genomic and diagnostic data collection and drives big data questions and answers requiring a solid infrastructural foundation.

For this Topic, we invite original research papers and reviews with areas of interest related to large-scale collaborative neuroscience. Some potential areas of focus include:
*reliability, reproducibility and data assurance in common brain measures across various types of scans or software (eg research vs clinical quality, children vs adult, variability in regional reliability across different software etc)
*large-scale informatics approaches to big-data neuroscience and/or genomics
*exploring the variability and diversity in neuroimaging traits and applications
* reliability in brain networks, including structural or functional connections and patterns of genomic correlations across brain regions
* statistical approaches for big data imaging and/or genomics
* statistical approaches for pooling data (meta analyses comparisons, meta vs mega analyses)
*distributed or multisite machine learning across diverse datasets

While the scope of this Topic is broad, this issue will include only original works that analyze two or more diverse datasets and data sources.

Keywords: reliability, imaging genetics, meta-analysis, distributed computing, neuroimaging

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

     

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

     

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

     

Participating Journals

Impact

  • 119kTopic views
  • 95kArticle views
  • 20kArticle downloads
View impact