About this Research Topic
The relationship between cell death and cancer immunology has been addressed for decades with different approaches because cell death has an immunomodulatory activity involved in the origin, progression and metastasis of tumors. Specifically, efforts have been devoted to:
1) ascertaining the role of the immune system in the resistance to cell death by tumor cells,
2) discerning how, paradoxically, cell death can lead to immunosuppression that favors tumor progression,
3) explaining the mechanisms by which cell death induces tumor immunogenicity,
4) studying how dead, or dying, tumor cells exert an immunomodulatory effect on their tumor microenvironment,
5) investigating how tumor cell death is induced by different types of immunotherapy.
Given the complex connection between cancer immunology and cell death, this collection of articles aims to show the latest advances and to give an update in this field. On the one hand, our interest is to address how the immune system affects the cell death of tumor cells both during tumor development (including origin, progression and metastasis) and throughout its involvement in the different treatments. On the other hand, to deepen in how the different anticancer treatments affect the immune system and how all this affects the tumor response.
We welcome the submission of Original Research Articles, Reviews and Mini-reviews, including but not limited to the following topics:
1. Immunotherapy tumor cell death mechanisms and consequences on the immune system
2. TME modulation by cell death in tumor cells
3. Impact of cell death molecules on innate and adaptive immune cells in TME (i.e. immunotherapy stimulation of DC maturation and consequences on tumor antigen presentation; apoptotic Tregs induce higher immunosuppressive effect than live Tregs)
4. Immunogenic cell death in cancer treatments on clinical trials
5. Mechanisms governing cell death induction of tumor immunogenicity.
Please note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
1) ascertaining the role of the immune system in the resistance to cell death by tumor cells,
2) discerning how, paradoxically, cell death can lead to immunosuppression that favors tumor progression,
3) explaining the mechanisms by which cell death induces tumor immunogenicity,
4) studying how dead, or dying, tumor cells exert an immunomodulatory effect on their tumor microenvironment,
5) investigating how tumor cell death is induced by different types of immunotherapy.
Given the complex connection between cancer immunology and cell death, this collection of articles aims to show the latest advances and to give an update in this field. On the one hand, our interest is to address how the immune system affects the cell death of tumor cells both during tumor development (including origin, progression and metastasis) and throughout its involvement in the different treatments. On the other hand, to deepen in how the different anticancer treatments affect the immune system and how all this affects the tumor response.
We welcome the submission of Original Research Articles, Reviews and Mini-reviews, including but not limited to the following topics:
1. Immunotherapy tumor cell death mechanisms and consequences on the immune system
2. TME modulation by cell death in tumor cells
3. Impact of cell death molecules on innate and adaptive immune cells in TME (i.e. immunotherapy stimulation of DC maturation and consequences on tumor antigen presentation; apoptotic Tregs induce higher immunosuppressive effect than live Tregs)
4. Immunogenic cell death in cancer treatments on clinical trials
5. Mechanisms governing cell death induction of tumor immunogenicity.
Please note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: Cell Death, oncoimmunology, cancer, immunology, cancer immunotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
