The DNA Replication Machinery as Therapeutic Targets

185.5K

views

31

authors

10

articles

The DNA Replication Machinery as Therapeutic Targets

185.5K

views

31

authors

10

articles

Editorial

21 May 2019

Editorial: The DNA Replication Machinery as Therapeutic Targets

Andrew F. Gardner

and

Zvi Kelman

8,944 views

5 citations

Editors

2

Andrew F Gardner

New England Biolabs

National Institute of Standards and Technology (NIST)

Impact

About

In all organisms, the DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Inhibitors of replication proteins are commonly used in anti-cancer and anti-viral therapies. This Research Topic will examine the normal functions of replication proteins and strategies to target each step during the replication process including helicases, replication and lesion bypass DNA polymerases, topoisomerases and DNA repair enzymes. Articles will discuss current strategies to develop drugs targeting DNA replication proteins as well as future outlooks and needs.

In all organisms, the DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Inhibitors of replication proteins are commonly used in anti-cancer and anti-viral therapies. This Research Topic will examine the normal functions of replication proteins and strategies to target each step during the replication process including helicases, replication and lesion bypass DNA polymerases, topoisomerases and DNA repair enzymes. Articles will discuss current strategies to develop drugs targeting DNA replication proteins as well as future outlooks and needs.

Download ebook

Share

Editors

Andrew F Gardner

New England Biolabs

National Institute of Standards and Technology (NIST)

Impact

185,471 Total views

152,854 Article views

28,209 Article downloads

4,408 Topic views

Published In

Journal Thumbnail

Frontiers in Molecular Biosciences

Molecular Diagnostics and Therapeutics

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic