Immune-mediated diseases are one of the most common diseases in children, and immune dysfunction or immune deficiency is also one of the most important pathogenic factors of respiratory, kidney, digestive system, nerves, heart, and other important organ dysfunction. However, the molecular mechanism of immune dysfunction or immune deficiency mediating the occurrence and development of these diseases has not yet been elucidated.
Primary immunodeficiency disease (PID) is an immune system-related disease by monogenic mutation. Now, there are more than 400 different forms of PID in the world. Clinical manifestations of PIDs are highly variable. Autoimmunity and autoinflammation are highly involved in PID clinical practice and research, which highlight their importance and interdisciplinarity with immune-mediated diseases such as rheumatic and kidney diseases.
Immune-mediated glomerular diseases refer to a group of renal diseases including primary glomerular disease, such as idiopathic glomerulonephritis, which presents as minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS) according to the pathological phenotype, IgA nephropathy, idiopathic membranous nephropathy, as well as secondary glomerular disease, is a major part of children’s glomerular disease.
Despite the differences in etiology and phenotypic variations, they may have common genetic associations, treatment responses, and clinical presentation. Early consultation with a clinical immunologist is essential, as timely diagnosis and treatment are imperative for preventing significant disease-associated morbidity. Treating PID, immune-mediated kidney diseases, and rheumatic diseases still focuses on pathology and precise medicine.
The goal of this Research Topic is to provide a forum to advance the attempt and promotion of precision medicine research models for immune-mediated diseases such as PID, Immune-mediated glomerular diseases, autoimmunity, and autoinflammation disease. High priority will be given to research focusing on clinical research, such as immune-related real-world research, genetic molecular mechanisms, multi-omics research, and further mechanistic insights. This Research Topic will address and discuss recent advances and future research directions on biomarkers for early diagnosis, specific intervention targets, and disease models so that readers can have a broad overview of this research area spanning from the fundamentals to the therapeutics.
The bullet points include but are not limited to the following:
1) Study on the molecular mechanism and signaling pathway of the occurrence and development of immune-mediated diseases.
2) Precise diagnosis, typing, and treatment of immune-mediated diseases in children.
3) Research on genetic or multi-omics research in immune-mediated glomerular diseases, autoimmune and autoinflammatory diseases.
4) Construction of animal models and a molecular chip to simulate PID.
Immune-mediated diseases are one of the most common diseases in children, and immune dysfunction or immune deficiency is also one of the most important pathogenic factors of respiratory, kidney, digestive system, nerves, heart, and other important organ dysfunction. However, the molecular mechanism of immune dysfunction or immune deficiency mediating the occurrence and development of these diseases has not yet been elucidated.
Primary immunodeficiency disease (PID) is an immune system-related disease by monogenic mutation. Now, there are more than 400 different forms of PID in the world. Clinical manifestations of PIDs are highly variable. Autoimmunity and autoinflammation are highly involved in PID clinical practice and research, which highlight their importance and interdisciplinarity with immune-mediated diseases such as rheumatic and kidney diseases.
Immune-mediated glomerular diseases refer to a group of renal diseases including primary glomerular disease, such as idiopathic glomerulonephritis, which presents as minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS) according to the pathological phenotype, IgA nephropathy, idiopathic membranous nephropathy, as well as secondary glomerular disease, is a major part of children’s glomerular disease.
Despite the differences in etiology and phenotypic variations, they may have common genetic associations, treatment responses, and clinical presentation. Early consultation with a clinical immunologist is essential, as timely diagnosis and treatment are imperative for preventing significant disease-associated morbidity. Treating PID, immune-mediated kidney diseases, and rheumatic diseases still focuses on pathology and precise medicine.
The goal of this Research Topic is to provide a forum to advance the attempt and promotion of precision medicine research models for immune-mediated diseases such as PID, Immune-mediated glomerular diseases, autoimmunity, and autoinflammation disease. High priority will be given to research focusing on clinical research, such as immune-related real-world research, genetic molecular mechanisms, multi-omics research, and further mechanistic insights. This Research Topic will address and discuss recent advances and future research directions on biomarkers for early diagnosis, specific intervention targets, and disease models so that readers can have a broad overview of this research area spanning from the fundamentals to the therapeutics.
The bullet points include but are not limited to the following:
1) Study on the molecular mechanism and signaling pathway of the occurrence and development of immune-mediated diseases.
2) Precise diagnosis, typing, and treatment of immune-mediated diseases in children.
3) Research on genetic or multi-omics research in immune-mediated glomerular diseases, autoimmune and autoinflammatory diseases.
4) Construction of animal models and a molecular chip to simulate PID.
