Research on the epidemiology, diagnosis, and treatment of nasal cavity and paranasal sinus cancers requires greater investigation. These rare cancers account for 3-5% of head and neck neoplasms and less than 1% of all human malignancies. They are characterized by significant histological heterogeneity, diverse aetiology, biology, and clinical features, and different prognoses. Risk factors include occupational exposure to substances like wood and leather dust, textiles, and organic solvents, as well as non-occupational factors such as tobacco use, nasal polyposis, inverted sinusal papilloma, and radiation exposure. The WHO classification of these neoplasms was updated in 2022, introducing several new molecular entities. However, due to the rarity of these cancers, evidence-based therapeutic strategies are lacking, and the outcome is usually poor.The goal of this Research Topic is to provide a comprehensive overview of these rare cancers, from epidemiology to treatment. The aim is to invite authors with different areas of expertise to contribute to this collection with original research, review articles, brief research reports, general commentary, and case reports. The hope is that this will lead to a better understanding of these cancers, their risk factors, and potential treatment strategies, ultimately improving patient outcomes.The scope of this Research Topic is limited to cancers of the nasal cavity and paranasal sinuses. Nasopharyngeal cancer and salivary gland neoplasms of the sinonasal tract, as well as hematologic malignancies, are outside the scope of this collection and will not be accepted. Additionally, manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases without validation (independent cohort or biological validation in vitro or in vivo) are also outside the scope of this section. Themes pertinent to this Research Topic include, but are not limited to:- Epidemiology of nasal cavity and paranasal sinus cancers- Risk factors and aetiology- Diagnosis and histopathologic classification- Treatment strategies and outcomes- Molecular profiling and actionable alterations- Multidisciplinary management of these cancers
Research on the epidemiology, diagnosis, and treatment of nasal cavity and paranasal sinus cancers requires greater investigation. These rare cancers account for 3-5% of head and neck neoplasms and less than 1% of all human malignancies. They are characterized by significant histological heterogeneity, diverse aetiology, biology, and clinical features, and different prognoses. Risk factors include occupational exposure to substances like wood and leather dust, textiles, and organic solvents, as well as non-occupational factors such as tobacco use, nasal polyposis, inverted sinusal papilloma, and radiation exposure. The WHO classification of these neoplasms was updated in 2022, introducing several new molecular entities. However, due to the rarity of these cancers, evidence-based therapeutic strategies are lacking, and the outcome is usually poor.The goal of this Research Topic is to provide a comprehensive overview of these rare cancers, from epidemiology to treatment. The aim is to invite authors with different areas of expertise to contribute to this collection with original research, review articles, brief research reports, general commentary, and case reports. The hope is that this will lead to a better understanding of these cancers, their risk factors, and potential treatment strategies, ultimately improving patient outcomes.The scope of this Research Topic is limited to cancers of the nasal cavity and paranasal sinuses. Nasopharyngeal cancer and salivary gland neoplasms of the sinonasal tract, as well as hematologic malignancies, are outside the scope of this collection and will not be accepted. Additionally, manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases without validation (independent cohort or biological validation in vitro or in vivo) are also outside the scope of this section. Themes pertinent to this Research Topic include, but are not limited to:- Epidemiology of nasal cavity and paranasal sinus cancers- Risk factors and aetiology- Diagnosis and histopathologic classification- Treatment strategies and outcomes- Molecular profiling and actionable alterations- Multidisciplinary management of these cancers