Personalized Therapies for Monogenic Diabetes

  • 2,312

    Total downloads

  • 8,529

    Total views and downloads

Submit your idea

Select the journal/section where you want your idea to be submitted:

Submit your manuscript summarySubmit your manuscript

About this Research Topic

Submission closed

Background

Monogenic diabetes has three main clinical forms: Maturity Onset Diabetes of the Young (MODY), Neonatal Diabetes Mellitus (NDM), and the syndromes of Severe Insulin Resistance (SIRs). The first two conditions are caused by pathogenic variants in genes that affect pancreatic beta cell function. MODY is an autosomal dominant condition. Among MODY genes, four are considered common: GCK, HNF1A, HNF4A, and HNF1B. While carriers of GCK variants do not need any treatment, patients bearing either HNF1A or HNF4A mutations can respond to oral hypoglycemic agents (OHA) of the class of sulfonylureas or other forms of therapy different from insulin. Another subtype, i.e., the maternally inherited diabetes linked to the frequent mitochondrial mutation m.3243A>G, is actionable and can respond to OHA. Among the 40-something beta cell genes that can cause NDM, at least two (KCNJ11 and ABCC8) account for more than 50% of cases that are actionable, with most carriers reaching optimal metabolic control with sulfonylureas. About 50% of patients with transient neonatal diabetes mellitus (TNDM) may relapse around adolescence and are usually treated with sulfonylureas. Finally, SIRs, depending on subtype, may respond to human recombinant IGF1, leptin, thiazolidinediones, and SGLT2 inhibitors.

This Research Topic aims to provide an updated view of all the different options of treatments for patients with monogenic diabetes. Thus papers on various treatment(s) for patients with pathogenic or likely pathogenic variants in HNF1A, HNF4A, HNF1B, or with m.3243A>G are welcome. In addition, treatment for permanent NDM (PNDM) may vary according to disease pathophysiology (e.g., beta cell defect versus pancreas agenesis or specific therapies for syndromic forms). By paying close attention to the mechanisms of disease and appropriate drug choice for any specific condition (precision medicine) we would like to highlight new treatments and modern ways to administer old therapies. This applies also to various forms of SIRs with diabetes some of which are very difficult to treat. Finally, a goal would be to provide very detailed procedures for adapting current therapies to neonates with very small birth weights, a major hurdle for clinicians.

We welcome mini reviews on specific topics (e.g. sulfonylureas for treating hyperglycemia of patients of any age with diabetes caused by mutations in the KATP channels; treatments for genetic forms of severe insulin resistance, treatments for PNDM due to pancreas agenesis, treatments for autoimmune monogenic PNDM), as well as original data possibly on more than a single case. For case reports bearing pathogenic variants in frequent (HNF1A and HNF4A), actionable MODY genes we suggest presenting data on multiple cases rather than single ones.

All papers must provide full information on the genetic data of patients/conditions described in the manuscript. This will allow an informed judgment on the benefits and/or pitfalls of certain treatments in individuals with a specific monogenic condition associated with diabetes.

All submissions must be in scope for the journal and section to which the article was submitted. Follow journal guidelines for article submission. In particular, Case Reports must include annotated CARE guidelines. Other articles are encouraged to include an annotated EQUATOR checklist appropriate for their article type.

Keywords: Monogenic diabetes, Personalized therapies, Pathogenic variants

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

     

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

     

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

     

Participating Journals

Impact

  • 8,529Topic views
  • 5,142Article views
  • 2,312Article downloads
View impact