GABAergic inhibitory interneurons play a critical role in balancing and shaping neural network activity in mammalian brains. Their malformation and malfunction lead to a variety of brain disorders such as depression, autism, schizophrenia, and epilepsy. Thus, development, plasticity, and function of inhibitory circuits have been major research themes that attract many neuroscientists from broad areas. However, it has not been straightforward to study the inhibitory system because of the high degree of cell-type diversity. Nevertheless, recent unprecedented advances in genetics, molecular tools to measure/manipulate neuronal activity and signaling, imaging techniques, and omics techniques have begun to elucidate the novel cellular and molecular mechanisms that play a key role in assembly, plasticity, function, and malfunction of inhibitory interneurons with cell type-specific resolution.
In this Research Topic, we would like to highlight our up-to-date understanding of the cellular and molecular mechanisms that play an essential role in development, plasticity, and function of inhibitory interneurons as well as their malfunction that is associated with brain disorders. We would also like to review multiple cutting-edge techniques that allow researchers to disentangle the complexity of cell-type heterogeneity and elucidate multiple aspects of neurobiological issues. The remaining questions and technical obstacles to be addressed should be discussed as well. To achieve this goal, we will call for manuscripts from broad areas including development, plasticity, circuit function, translational research, and technical development that target mammalian species.
Subjects in this Research Topic should focus on inhibitory interneurons in the mammalian forebrain. We expect to see a manuscript in the format of Reviews or Original Article including but not limited to the following subjects:
- specification of interneuron lineages and subtypes.
- glia-interneuron interactions underlying neuronal migration and synapse refinement.
- the molecular and cellular interactions controlling synapse formation and specificity of interneurons.
- epigenetic control of the development and function of interneurons.
- remote control of interneuron differentiation and maturation by subcortical neurons
- activity-dependent interneuron death.
- the role of inhibitory circuits in sensory processing, cognition, and memory.
- the molecular and cellular etiology of brain disorders, E-I balance, excitatory GABA, GABA uptake.
- development and function of interneurons in brain organoids.
- differentiation of iPSCs into interneurons.
- genetic tools and techniques to interrogate inhibitory circuit development and function, cell type-specific omics technologies, tissue clearing, and imaging techniques.
GABAergic inhibitory interneurons play a critical role in balancing and shaping neural network activity in mammalian brains. Their malformation and malfunction lead to a variety of brain disorders such as depression, autism, schizophrenia, and epilepsy. Thus, development, plasticity, and function of inhibitory circuits have been major research themes that attract many neuroscientists from broad areas. However, it has not been straightforward to study the inhibitory system because of the high degree of cell-type diversity. Nevertheless, recent unprecedented advances in genetics, molecular tools to measure/manipulate neuronal activity and signaling, imaging techniques, and omics techniques have begun to elucidate the novel cellular and molecular mechanisms that play a key role in assembly, plasticity, function, and malfunction of inhibitory interneurons with cell type-specific resolution.
In this Research Topic, we would like to highlight our up-to-date understanding of the cellular and molecular mechanisms that play an essential role in development, plasticity, and function of inhibitory interneurons as well as their malfunction that is associated with brain disorders. We would also like to review multiple cutting-edge techniques that allow researchers to disentangle the complexity of cell-type heterogeneity and elucidate multiple aspects of neurobiological issues. The remaining questions and technical obstacles to be addressed should be discussed as well. To achieve this goal, we will call for manuscripts from broad areas including development, plasticity, circuit function, translational research, and technical development that target mammalian species.
Subjects in this Research Topic should focus on inhibitory interneurons in the mammalian forebrain. We expect to see a manuscript in the format of Reviews or Original Article including but not limited to the following subjects:
- specification of interneuron lineages and subtypes.
- glia-interneuron interactions underlying neuronal migration and synapse refinement.
- the molecular and cellular interactions controlling synapse formation and specificity of interneurons.
- epigenetic control of the development and function of interneurons.
- remote control of interneuron differentiation and maturation by subcortical neurons
- activity-dependent interneuron death.
- the role of inhibitory circuits in sensory processing, cognition, and memory.
- the molecular and cellular etiology of brain disorders, E-I balance, excitatory GABA, GABA uptake.
- development and function of interneurons in brain organoids.
- differentiation of iPSCs into interneurons.
- genetic tools and techniques to interrogate inhibitory circuit development and function, cell type-specific omics technologies, tissue clearing, and imaging techniques.
