Paradoxical Reaction through Immune-related Dermatoses: Mechanism and Treatment Strategy

Biologics play a positive and effective role in the treatment of psoriasis and atopic dermatitis (AD). Nevertheless, many cases of other immune-related diseases also manifest along with the process of biologics treatment, such as AD in psoriasis, inflammatory bowel disease in psoriasis, and psoriatic skin lesions in AD, as well as exacerbation of SLE and occurrence of rheumatoid arthritis. The mechanism underlying the paradoxical reactions is currently unclear. Since both psoriasis and AD are T-cell-mediated inflammatory skin diseases that share common genes and signaling pathways, such treatment may lead to T-cell polarization imbalance, which is evidenced by the similar eczema-like adverse reactions caused by biological therapy for psoriasis.

The aim of this Research Topic is to provide a forum for advancing research into the mechanisms and therapeutic strategies of paradoxical reactions in immune-related skin diseases, as well as paradoxical reactions between eczematous eruptions and psoriasiform lesions.

We welcome submissions of Original Research and Review articles, including but not limited to the following:
1) Explore the inflammatory mechanisms of paradoxical reaction between eczematous eruption and psoriasiform lesions;
2) Treatment strategy for the paradoxical reaction of immune-related dermatoses;
3) Polarization of T cells in AD and psoriasis;
4) Clinical trials against immune-related dermatoses;
5) AD phenotype and paradoxical reaction;
6) Genetic and immune-inflammatory pathways in AD and psoriasis;
7) Potential mechanism of paradoxical reaction induced by biologics;
8) Treatment strategies for biologics-related adverse reactions.

Please NOTE: Manuscripts describing the pharmacological action of drugs used in traditional medicine are not in scope unless they have a strong focus on the immune system.