Cytokines and soluble mediators in reprogramming of tumor microenvironment

7.6K

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23

authors

3

articles

Cytokines and soluble mediators in reprogramming of tumor microenvironment

7.6K

views

23

authors

3

articles

Editors

5

Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University

The First Affiliated Hospital of Soochow University

Jinan University

Peking University People's Hospital

University of Houston

Impact

Review

30 August 2024

Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy

Ludovica Lopresti

, 2 more and

Laura Patrussi

2,986 views

4 citations

Original Research

23 May 2024

Predicting chemotherapy toxicity in multiple myeloma: the prognostic value of pre-treatment serum cytokine levels of interleukin-6, interleukin-8, monocyte chemoattractant protein-1, and vascular endothelial growth factor

Michał Mielnik

, 5 more and

Marek Hus

2,149 views

0 citations

Original Research

02 October 2024

Haptoglobin buffers lipopolysaccharides to delay activation of NFκB

Laura Zein

, 10 more and

Ho-Ryun Chung

1,418 views

0 citations

Open for submission

Frontiers in Immunology

Cytokine Interactions and Biomarker Potential in Various Diseases

Edited by Ashwin Kotnis, Tarun Kumar Upadhyay

Deadline

24 October 2025

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About

The immunotherapeutic response is associated with dramatic modifications in the tumor microenvironment (TME). Cytokines and soluble proteins mediate intercellular signaling regulation, modulation of cell metabolism, and TME reprogramming. Cancer cells educate innate immune cells through excreting cytokines, and many metabolites in the TME influence differentiation and recruitment of immunosuppressive cells, thus leading to immunosuppressive TME. Recently, accumulating evidence has identified that modulation of cytokines or soluble mediators in TME could enhance T cell function and might be a promising cancer immunotherapeutic approach. In the era of cancer immunotherapy, cytokines, and soluble mediators not only function as biomarkers of immunosuppressive TME, guiding individualized immunotherapy, but also represent essential therapeutic targets in anti-cancer treatment.

This Research Topic aims to provide a forum to advance research on the role of cytokines or soluble mediators in the reprogramming of tumor microenvironment and to explore novel therapeutic strategies targeting cytokines and soluble mediators.

- Mechanism of metabolites in regulating the tumor microenvironment
- Cytokines or soluble mediators as biomarkers of immunotherapeutic response (including immunochemotherapy, CAR-T, ASCT, and allo-SCT) in hematological malignancies
- Novel therapeutic strategies targeting cytokines or soluble mediators

The immunotherapeutic response is associated with dramatic modifications in the tumor microenvironment (TME). Cytokines and soluble proteins mediate intercellular signaling regulation, modulation of cell metabolism, and TME reprogramming. Cancer cells educate innate immune cells through excreting cytokines, and many metabolites in the TME influence differentiation and recruitment of immunosuppressive cells, thus leading to immunosuppressive TME. Recently, accumulating evidence has identified that modulation of cytokines or soluble mediators in TME could enhance T cell function and might be a promising cancer immunotherapeutic approach. In the era of cancer immunotherapy, cytokines, and soluble mediators not only function as biomarkers of immunosuppressive TME, guiding individualized immunotherapy, but also represent essential therapeutic targets in anti-cancer treatment.

This Research Topic aims to provide a forum to advance research on the role of cytokines or soluble mediators in the reprogramming of tumor microenvironment and to explore novel therapeutic strategies targeting cytokines and soluble mediators.

- Mechanism of metabolites in regulating the tumor microenvironment
- Cytokines or soluble mediators as biomarkers of immunotherapeutic response (including immunochemotherapy, CAR-T, ASCT, and allo-SCT) in hematological malignancies
- Novel therapeutic strategies targeting cytokines or soluble mediators

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Editors

Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University

The First Affiliated Hospital of Soochow University

Jinan University

Peking University People's Hospital

University of Houston

Impact

7,630 Total views

4,657 Article views

2,154 Article downloads

819 Topic views

Published In

Frontiers in Immunology

Cytokines and Soluble Mediators in Immunity

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