DNA methylation and histone changes, among other epigenetic modifications, are essential for neural function. Studying these alterations in the nervous system, also known as neuroepigenetics, sheds light on how gene expression can be changed without affecting the underlying DNA sequence. Recent studies have highlighted the importance of epigenetic abnormalities and dysregulation in psychiatric disorders like schizophrenia, neurodegenerative diseases including Alzheimer's Disease and Parkinson's Disease, and cognitive deficits associated with conditions like Autism Spectrum Disorder. By understanding these epigenetic modifications, as well brain development, memory formation, behavior, and disease, novel therapeutic approaches may be made possible.
This Research Topic focuses on investigating the most recent discoveries and advancements in the epigenetic changes that underlie neurological and cognitive diseases. It seeks to increase our knowledge of the complex interactions that exist between epigenetic changes and the beginning and development of neurological and cognitive illnesses. Although there is strong evidence linking epigenetic dysregulation to a number of different neurological conditions, the exact processes behind these connections are still unknown. Consolidating existing studies and igniting fresh inquiries into the function and malfunction of DNA methylation, histone modification, and other epigenetic pathways are essential first steps in closing this knowledge gap.
Studying the complex neuroepigenetic landscape has been made possible due to recent developments in genomic technologies and epigenetic editing techniques. With the help of cutting-edge methods including single cell sequencing and high-resolution epigenome mapping, we can identify particular epigenetic changes in the brain that affect different cell types. Targeted epigenetic editing technologies like CRISPR-dCas9 systems have unprecedented prospects for the mechanistic investigation of neuroepigenetics.
With the help of this Research Topic, we hope to compile a range of studies that investigate how DNA methylation, histone modifications, and other epigenetic processes contribute to the onset and progression of neurological and cognitive disorders. Additionally, we want to explore new ideas for using these epigenetic alterations for therapeutic purposes.
We welcome original research articles, reviews, mini-reviews, and perspectives on, but not limited to, any of the following topics:
1. Mechanistic studies investigating the roles of specific epigenetic modifications in neurological function and dysfunction.
2. Epigenetic changes associated with cognitive impairment in neurodevelopmental and neurodegenerative disorders.
3. The influence of environmental factors on neuroepigenetic regulation.
4. Advances in epigenomic technologies and their application in neuroscience.
5. Therapeutic potential of epigenetic interventions for neurological and cognitive disorders.
Through this topic, we aim to create a vibrant discussion and present cutting-edge research in the rapidly evolving field of neuroepigenetics. We look forward to contributions that explore novel insights, challenge current thinking, and propose new directions for future research.
DNA methylation and histone changes, among other epigenetic modifications, are essential for neural function. Studying these alterations in the nervous system, also known as neuroepigenetics, sheds light on how gene expression can be changed without affecting the underlying DNA sequence. Recent studies have highlighted the importance of epigenetic abnormalities and dysregulation in psychiatric disorders like schizophrenia, neurodegenerative diseases including Alzheimer's Disease and Parkinson's Disease, and cognitive deficits associated with conditions like Autism Spectrum Disorder. By understanding these epigenetic modifications, as well brain development, memory formation, behavior, and disease, novel therapeutic approaches may be made possible.
This Research Topic focuses on investigating the most recent discoveries and advancements in the epigenetic changes that underlie neurological and cognitive diseases. It seeks to increase our knowledge of the complex interactions that exist between epigenetic changes and the beginning and development of neurological and cognitive illnesses. Although there is strong evidence linking epigenetic dysregulation to a number of different neurological conditions, the exact processes behind these connections are still unknown. Consolidating existing studies and igniting fresh inquiries into the function and malfunction of DNA methylation, histone modification, and other epigenetic pathways are essential first steps in closing this knowledge gap.
Studying the complex neuroepigenetic landscape has been made possible due to recent developments in genomic technologies and epigenetic editing techniques. With the help of cutting-edge methods including single cell sequencing and high-resolution epigenome mapping, we can identify particular epigenetic changes in the brain that affect different cell types. Targeted epigenetic editing technologies like CRISPR-dCas9 systems have unprecedented prospects for the mechanistic investigation of neuroepigenetics.
With the help of this Research Topic, we hope to compile a range of studies that investigate how DNA methylation, histone modifications, and other epigenetic processes contribute to the onset and progression of neurological and cognitive disorders. Additionally, we want to explore new ideas for using these epigenetic alterations for therapeutic purposes.
We welcome original research articles, reviews, mini-reviews, and perspectives on, but not limited to, any of the following topics:
1. Mechanistic studies investigating the roles of specific epigenetic modifications in neurological function and dysfunction.
2. Epigenetic changes associated with cognitive impairment in neurodevelopmental and neurodegenerative disorders.
3. The influence of environmental factors on neuroepigenetic regulation.
4. Advances in epigenomic technologies and their application in neuroscience.
5. Therapeutic potential of epigenetic interventions for neurological and cognitive disorders.
Through this topic, we aim to create a vibrant discussion and present cutting-edge research in the rapidly evolving field of neuroepigenetics. We look forward to contributions that explore novel insights, challenge current thinking, and propose new directions for future research.