About this Research Topic
Neuroinflammation manifests as changes to cognition or behavior, or as altered function in peripheral tissues. Patients with metabolic diseases (e.g., diabetes, obesity) are more likely to suffer with neuroinflammation since the disrupted metabolism and chronic low-grade inflammation that accompany metabolic diseases extends to the nervous system. Neuroinflammation will then lead to functional impairment and progressive loss of neuronal structure, with neurodegeneration being the end result. Factors like chronic hyperglycemia, dyslipidemia and insulin resistance are candidate drivers of neuroinflammation and neurodegeneration. The effects on the nervous system also contribute to worsening insulin resistance and a further loss of metabolic function and homeostasis in innervated peripheral tissues (e.g., liver, adipose tissue). Persistent metabolic stress predisposes patients to peripheral neuropathies, cognitive dysfunction, and development of neurodegenerative diseases (e.g., Alzheimer’s disease). Multiple associations link metabolic disease to neuropathology, targeting neuroinflammation to preserve neuronal integrity holds promise for managing metabolic diseases and associated neurological complications.
Research on "Neuroinflammation, Neurodegeneration and Metabolic Disease: From Molecular Mechanisms to Therapeutic Innovation" is necessary to address several critical gaps in our understanding and treatment of metabolic diseases and of neuropathology.
Firstly, while the role of systemic inflammation in metabolic diseases has been extensively studied, the specific impact of nervous system inflammation – neuroinflammation – and resulting neurodegeneration on these conditions is still an emerging field. Investigating the mechanisms by which neuroinflammation and neurodegeneration contribute to metabolic diseases can provide valuable insights into the pathogenesis and progression of these conditions.
Secondly, understanding the interplay between neuroinflammation, neurodegeneration, and metabolic diseases can uncover potential therapeutic targets. Recent advances in research have shed light on specific molecular pathways and cellular mechanisms involved in neuroinflammation and neurodegeneration. Developing therapeutic strategies to targeting these pathways holds promise for preventing or reversing the neurological complications associated with metabolic diseases.
Lastly, recent studies have highlighted the bidirectional communication between the brain and peripheral tissues, emphasizing the importance of the brain's role in metabolic regulation. Investigating the impact of neuroinflammation and neurodegeneration in metabolic diseases can provide a comprehensive understanding of the complex interactions between the central nervous system and peripheral metabolism.
We welcome work addressing molecular mechanisms, cellular interactions, technical, clinical and therapeutic aspects in neuroinflammation and neurodegeneration research. We also welcome research on neuropathological alterations with a focus on metabolic consequences or mechanisms.
Themes include:
1. Molecular mechanisms of neuroinflammation and neurodegeneration.
2. Cellular metabolism of neuronal cells or of neuron-interacting immune cells
3. The neuroimmune axis in metabolic diseases and in neurodegeneration
4. Roles of dysmetabolism (e.g., hyperglycemia, dyslipidemia) in neuropathology.
5. Physiology and pathophysiology relating to neuronal dysfunction and metabolism.
6. Dysmetabolism and its effect on mood, behavior, and cognition.
7. Consequences of neuroinflammation and neurodegeneration on cognition and metabolism.
8. Interplay between systemic and central inflammation, exploring bidirectional communication.
9. Clinical implications, diagnostic and predictive markers: Clinical phenotypes and potential biomarkers associated with neuroinflammation and neurodegeneration.
10. Novel therapeutic targets, interventions, and treatment strategies to mitigate the effects of neuroinflammation and neurodegeneration
11. Technical innovation and advances in neuroscience, neurometabolism and neuroimmunology
The collection should include original research, reviews, meta-analyses, clinical studies, short reports, or any other format that provides novel insights. Contributions from diverse disciplines such as neuroscience, metabolism and immunology are encouraged.
Research on "Neuroinflammation, Neurodegeneration and Metabolic Disease: From Molecular Mechanisms to Therapeutic Innovation" is necessary to address several critical gaps in our understanding and treatment of metabolic diseases and of neuropathology.
Firstly, while the role of systemic inflammation in metabolic diseases has been extensively studied, the specific impact of nervous system inflammation – neuroinflammation – and resulting neurodegeneration on these conditions is still an emerging field. Investigating the mechanisms by which neuroinflammation and neurodegeneration contribute to metabolic diseases can provide valuable insights into the pathogenesis and progression of these conditions.
Secondly, understanding the interplay between neuroinflammation, neurodegeneration, and metabolic diseases can uncover potential therapeutic targets. Recent advances in research have shed light on specific molecular pathways and cellular mechanisms involved in neuroinflammation and neurodegeneration. Developing therapeutic strategies to targeting these pathways holds promise for preventing or reversing the neurological complications associated with metabolic diseases.
Lastly, recent studies have highlighted the bidirectional communication between the brain and peripheral tissues, emphasizing the importance of the brain's role in metabolic regulation. Investigating the impact of neuroinflammation and neurodegeneration in metabolic diseases can provide a comprehensive understanding of the complex interactions between the central nervous system and peripheral metabolism.
We welcome work addressing molecular mechanisms, cellular interactions, technical, clinical and therapeutic aspects in neuroinflammation and neurodegeneration research. We also welcome research on neuropathological alterations with a focus on metabolic consequences or mechanisms.
Themes include:
1. Molecular mechanisms of neuroinflammation and neurodegeneration.
2. Cellular metabolism of neuronal cells or of neuron-interacting immune cells
3. The neuroimmune axis in metabolic diseases and in neurodegeneration
4. Roles of dysmetabolism (e.g., hyperglycemia, dyslipidemia) in neuropathology.
5. Physiology and pathophysiology relating to neuronal dysfunction and metabolism.
6. Dysmetabolism and its effect on mood, behavior, and cognition.
7. Consequences of neuroinflammation and neurodegeneration on cognition and metabolism.
8. Interplay between systemic and central inflammation, exploring bidirectional communication.
9. Clinical implications, diagnostic and predictive markers: Clinical phenotypes and potential biomarkers associated with neuroinflammation and neurodegeneration.
10. Novel therapeutic targets, interventions, and treatment strategies to mitigate the effects of neuroinflammation and neurodegeneration
11. Technical innovation and advances in neuroscience, neurometabolism and neuroimmunology
The collection should include original research, reviews, meta-analyses, clinical studies, short reports, or any other format that provides novel insights. Contributions from diverse disciplines such as neuroscience, metabolism and immunology are encouraged.
Keywords: Inflammation, Cognitive dysfunction, Central-Peripheral crosstalk, Insulin resistance, Hyperglycemia, Lipotoxicity, Diabetes, Metabolic syndrome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
