The Role of Gut Microbes and Their Metabolites in Immune-related Diseases, volume II

95.6K

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146

authors

17

articles

The Role of Gut Microbes and Their Metabolites in Immune-related Diseases, volume II

95.6K

views

146

authors

17

articles

Editors

5

Chuanxing Xiao

School of Medicine, Xiamen University

Xiangtian Yu

Shanghai Sixth People's Hospital, Shanghai Jiao Tong University

Qinglong Wu

International Flavors and Fragrances

Zhe-Sheng Chen

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University

Wei Xu

Third Institute of Oceanography, State Oceanic Administration

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About

Given the success of Research Topic The Role of Gut Microbes and Their Metabolites in Immune-related Diseases and the rapidly evolving subject area, we are pleased to announce the launch of Volume II.

The digestive tracts of a healthy adult contain approximately about 10¹¹-10¹² microorganisms, including bacteria and archaea, collectively referred to as the gut microbiota or intestinal flora. An individual's gut microbial flora is unique, acting as a separate set of "genomes" in the body. Recent studies have confirmed that altered intestinal flora and their metabolites significantly affect a variety of biological behaviors, including metabolism, organ development and immune response, which are significantly associated with human diseases, including but not limited to gastrointestinal disorders, obesity, diabetes, cancer, and even neurological and neurodegenerative diseases such as depression, autism, anxiety, and Parkinson's disease.

It is now well recognized that gut microbiota and their metabolites can affect the body's immune system in various ways, thereby regulating the progression of multiple diseases, including but not limited to inflammatory bowel disease, cancers, and diabetes. For example, intestinal flora regulates the immune system by influencing the tryptophan metabolic pathway. Bacterial components are presented directly as antigens and activate the immune system. "Intercommunication" between bacteria and host cells induces the secretion of inflammation-associated cytokines, thus recruiting immune cells and regulating immune homeostasis.

Given the important role of the interaction between the immune system and the gastrointestinal microbiota in human disease. It is worth exploring the mechanism of their interaction and elucidating the relationship between the gut microbiome, immunity, and human diseases, which would be significant to identify potential therapeutic strategies and targets for related diseases.

We encourage the exploration of the etiology of human immune-related diseases from the perspective of gut microecology to address these challenging questions. Both original studies and review articles with the following contents are highly anticipated for publication.
• Molecular mechanisms of interaction between gut microbes /metabolites and immune system.
• Effect of gut microbes /metabolites on the immune system and immune-related diseases.
• New therapies and targets based on the interaction between gut microbes/metabolites and the immune system for related diseases.

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Editors

Chuanxing Xiao

School of Medicine, Xiamen University

Xiangtian Yu

Shanghai Sixth People's Hospital, Shanghai Jiao Tong University

Qinglong Wu

International Flavors and Fragrances

Zhe-Sheng Chen

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University

Wei Xu

Third Institute of Oceanography, State Oceanic Administration

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95,589 Total views

57,376 Article views

36,411 Article downloads

1,802 Topic views

Published In

Frontiers in Cellular and Infection Microbiology

Intestinal Microbiome

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