The human body is a complex ecosystem that is home to trillions of microorganisms collectively known as the microbiota. Recent research has shown that the gut microbiota plays a crucial role in maintaining overall health and well-being. The gut-kidney axis, the bidirectional communication between the gut and kidneys, has also been implicated in various physiological and pathological conditions, including kidney disease. The theme "Gut feelings: investigating the link between microbiota and kidney disease progression" aims to explore the latest advances in the field of microbiota and kidney disease, covering topics such as the molecular mechanisms underlying the effects of gut microbiota on kidney function, the role of gut-kidney axis in kidney disease progression, and potential therapeutic interventions targeting the gut microbiota to slow down or prevent the progression of kidney disease.The gut microbiota is involved in various physiological functions, including digestion, nutrient absorption, and metabolism, and communicates with the immune system and other organs through a complex network of signaling pathways. The gut-kidney axis is one such communication pathway that has recently gained attention from researchers. Emerging evidence suggests that the gut microbiota's composition and function can influence the kidneys' health and function, and conversely, kidney disease can alter the gut microbiota's composition and function.Chronic kidney disease (CKD) is a progressive and irreversible condition affecting millions of people worldwide and posing a significant economic burden on healthcare systems. The causes of CKD are multifactorial, with both genetic and environmental factors contributing to its development and progression. Recent studies have suggested that gut microbiota dysbiosis, an imbalance in the gut microbiota composition and function, may play a key role in CKD pathogenesis.This Research Topic welcomes original research articles, reviews, and perspectives that address the following topics:1. Molecular mechanisms underlying the effects of gut microbiota on kidney function: This topic covers studies that investigate the interactions between gut microbiota and kidney function at the molecular level. The studies may include in vitro or in vivo experiments that explore the mechanisms by which gut microbiota affects kidney function.2. Role of gut-kidney axis in kidney disease progression: This topic covers studies that investigate the bidirectional communication between the gut and the kidneys and its potential role in the progression of kidney disease. The studies may include animal models or clinical studies that examine the effects of gut-kidney axis modulation on kidney function.3. Potential therapeutic interventions targeting the gut microbiota to slow down or prevent the progression of kidney disease: This topic covers studies that investigate the potential of gut microbiota modulation as a therapeutic intervention to slow down or prevent the progression of kidney disease. The studies may include preclinical or clinical studies that evaluate the effects of probiotics, prebiotics, or other interventions targeting the gut microbiota on kidney function.
The human body is a complex ecosystem that is home to trillions of microorganisms collectively known as the microbiota. Recent research has shown that the gut microbiota plays a crucial role in maintaining overall health and well-being. The gut-kidney axis, the bidirectional communication between the gut and kidneys, has also been implicated in various physiological and pathological conditions, including kidney disease. The theme "Gut feelings: investigating the link between microbiota and kidney disease progression" aims to explore the latest advances in the field of microbiota and kidney disease, covering topics such as the molecular mechanisms underlying the effects of gut microbiota on kidney function, the role of gut-kidney axis in kidney disease progression, and potential therapeutic interventions targeting the gut microbiota to slow down or prevent the progression of kidney disease.The gut microbiota is involved in various physiological functions, including digestion, nutrient absorption, and metabolism, and communicates with the immune system and other organs through a complex network of signaling pathways. The gut-kidney axis is one such communication pathway that has recently gained attention from researchers. Emerging evidence suggests that the gut microbiota's composition and function can influence the kidneys' health and function, and conversely, kidney disease can alter the gut microbiota's composition and function.Chronic kidney disease (CKD) is a progressive and irreversible condition affecting millions of people worldwide and posing a significant economic burden on healthcare systems. The causes of CKD are multifactorial, with both genetic and environmental factors contributing to its development and progression. Recent studies have suggested that gut microbiota dysbiosis, an imbalance in the gut microbiota composition and function, may play a key role in CKD pathogenesis.This Research Topic welcomes original research articles, reviews, and perspectives that address the following topics:1. Molecular mechanisms underlying the effects of gut microbiota on kidney function: This topic covers studies that investigate the interactions between gut microbiota and kidney function at the molecular level. The studies may include in vitro or in vivo experiments that explore the mechanisms by which gut microbiota affects kidney function.2. Role of gut-kidney axis in kidney disease progression: This topic covers studies that investigate the bidirectional communication between the gut and the kidneys and its potential role in the progression of kidney disease. The studies may include animal models or clinical studies that examine the effects of gut-kidney axis modulation on kidney function.3. Potential therapeutic interventions targeting the gut microbiota to slow down or prevent the progression of kidney disease: This topic covers studies that investigate the potential of gut microbiota modulation as a therapeutic intervention to slow down or prevent the progression of kidney disease. The studies may include preclinical or clinical studies that evaluate the effects of probiotics, prebiotics, or other interventions targeting the gut microbiota on kidney function.