About this Research Topic
Immunotherapy has emerged as a transformative modality in the management of urologic malignancies, encompassing prostate, kidney, bladder, and testicular cancers. Historically, these malignancies have posed significant therapeutic challenges, with limited response rates to traditional modalities, such as chemotherapy and radiation. Immunotherapy harnesses the immune system's innate capacity to identify and eradicate cancer cells through a variety of mechanisms. Immune checkpoint inhibitors, in particular, have demonstrated substantial clinical efficacy in urologic malignancies by neutralizing proteins that serve to curtail immune system activation and impair recognition of tumor antigens. By removing these immunosuppressive barriers, immune checkpoint inhibitors augment anti-tumor immunity and foster durable responses in patients with urologic malignancies. Consequently, immunotherapy has garnered a pivotal role in the contemporary therapeutic landscape for urologic malignancies, with demonstrated improvement in survival outcomes and quality of life for affected individuals.
Given that immunotherapy has transformed the therapeutic landscape of urologic malignancies, it is imperative to comprehend the latest developments in this field and their clinical utility. This research topic aims to evaluate the safety and efficacy of diverse immunotherapy regimens in urologic malignancies, explore their mechanisms of action, and investigate the emergence of resistance. Furthermore, there is a critical need to identify new prognostic and predictive biomarkers that can assist in predicting the response to immune checkpoint inhibitors. Our objective is to assess the long-term outcomes of patients treated with immunotherapy for urologic malignancies and evaluate the impact of this therapy on patients' quality of life, including their physical and psychological well-being. The articles featured in this research topic will provide readers with a comprehensive understanding of the immune microenvironment in urologic malignancies, which may lead to the development of novel immunotherapeutic strategies.
We welcome articles covering the following topics:
1. The efficacy and safety of different types of immunotherapies in treating urologic malignancies, such as immune checkpoint inhibitors, CAR-T cells, and vaccines.
2. Mechanisms of action of immunotherapy and potential biomarkers that could predict response to treatment in urologic malignancies.
3. Impact of immunotherapy on the immune system and tumor microenvironment in urologic malignancies, including the potential for combination therapies with other modalities.
4. Resistance to immunotherapy in urologic malignancies.
5. Reviews summarizing the current state of knowledge on the use of immunotherapy in urologic malignancies, including the latest clinical data and future directions for research.
6. Cost-effectiveness analyses assessing the economic impact of using immunotherapy as a treatment option for urologic malignancies, including the potential benefits and drawbacks compared to other treatment modalities.
7. Case reports or case series detailing the clinical experiences and outcomes of patients with urologic malignancies treated with immunotherapy.
Given that immunotherapy has transformed the therapeutic landscape of urologic malignancies, it is imperative to comprehend the latest developments in this field and their clinical utility. This research topic aims to evaluate the safety and efficacy of diverse immunotherapy regimens in urologic malignancies, explore their mechanisms of action, and investigate the emergence of resistance. Furthermore, there is a critical need to identify new prognostic and predictive biomarkers that can assist in predicting the response to immune checkpoint inhibitors. Our objective is to assess the long-term outcomes of patients treated with immunotherapy for urologic malignancies and evaluate the impact of this therapy on patients' quality of life, including their physical and psychological well-being. The articles featured in this research topic will provide readers with a comprehensive understanding of the immune microenvironment in urologic malignancies, which may lead to the development of novel immunotherapeutic strategies.
We welcome articles covering the following topics:
1. The efficacy and safety of different types of immunotherapies in treating urologic malignancies, such as immune checkpoint inhibitors, CAR-T cells, and vaccines.
2. Mechanisms of action of immunotherapy and potential biomarkers that could predict response to treatment in urologic malignancies.
3. Impact of immunotherapy on the immune system and tumor microenvironment in urologic malignancies, including the potential for combination therapies with other modalities.
4. Resistance to immunotherapy in urologic malignancies.
5. Reviews summarizing the current state of knowledge on the use of immunotherapy in urologic malignancies, including the latest clinical data and future directions for research.
6. Cost-effectiveness analyses assessing the economic impact of using immunotherapy as a treatment option for urologic malignancies, including the potential benefits and drawbacks compared to other treatment modalities.
7. Case reports or case series detailing the clinical experiences and outcomes of patients with urologic malignancies treated with immunotherapy.
Keywords: Urologic malignancies, Immunotherapy, Immune checkpoint inhibitors, PD-L1, PD-1, CTLA-4, Tumor-immune microenvironment, prostate cancer, kidney cancer, bladder cancer, testicular cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
