Pigs are important agricultural animals with ancient domestication history and economic value and have become important sources of protein for humans. Infectious diseases affect the health of pigs and the stability and productivity of the global swine industry. The emergence and reemergence of several contagious swine diseases in recent years have posed a severe threat to pig production globally. Increasing concern has been raised about the immunosuppressive effect caused by immunosuppressive swine pathogens in recent years, such as porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus (PCV), African swine fever virus (ASFV), classical swine fever virus (CSFV), pseudorabies virus (PRV) among others. Infection with variant strains of PRRSV, PRV, and the low virulence strains of ASFV increase the pathogenicity of opportunistic infectious agents, causing secondary disease challenges, which can result in more complicated clinical symptoms and severe diseases. These diseases lead to increased treatment expenses, reduced swine herd growth rate, and feed conversion rate. However, with the ongoing viral evolution and the emergence of novel variants, current research into the mechanisms underlying immunosuppression remains inadequate, highlighting the urgent need for further investigation.The Research Topic aims to showcase high-quality research conducted by internationally recognized researchers in the field of immunosuppression-related swine disease. The primary focus of this Research Topic is to provide an up-to-date understanding of immunosuppression-related swine disease pathogen infections and mechanisms of immunosuppression, which include, but are not limited to the following subtopics:- Epidemiology, pathogenesis and pathology of immunosuppressive-related swine disease pathogens, including PRRSV, PCV, ASFV, CSFV, PRV, bacteria, mycoplasmas, and other relevant pathogens;- The underlying mechanisms that lead to immunosuppression caused by these pathogens, including those already mentioned above and others;- Studies that explore host-virus interactions, immunology and immune evasion;- Vaccines and disease control strategies.
Pigs are important agricultural animals with ancient domestication history and economic value and have become important sources of protein for humans. Infectious diseases affect the health of pigs and the stability and productivity of the global swine industry. The emergence and reemergence of several contagious swine diseases in recent years have posed a severe threat to pig production globally. Increasing concern has been raised about the immunosuppressive effect caused by immunosuppressive swine pathogens in recent years, such as porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus (PCV), African swine fever virus (ASFV), classical swine fever virus (CSFV), pseudorabies virus (PRV) among others. Infection with variant strains of PRRSV, PRV, and the low virulence strains of ASFV increase the pathogenicity of opportunistic infectious agents, causing secondary disease challenges, which can result in more complicated clinical symptoms and severe diseases. These diseases lead to increased treatment expenses, reduced swine herd growth rate, and feed conversion rate. However, with the ongoing viral evolution and the emergence of novel variants, current research into the mechanisms underlying immunosuppression remains inadequate, highlighting the urgent need for further investigation.The Research Topic aims to showcase high-quality research conducted by internationally recognized researchers in the field of immunosuppression-related swine disease. The primary focus of this Research Topic is to provide an up-to-date understanding of immunosuppression-related swine disease pathogen infections and mechanisms of immunosuppression, which include, but are not limited to the following subtopics:- Epidemiology, pathogenesis and pathology of immunosuppressive-related swine disease pathogens, including PRRSV, PCV, ASFV, CSFV, PRV, bacteria, mycoplasmas, and other relevant pathogens;- The underlying mechanisms that lead to immunosuppression caused by these pathogens, including those already mentioned above and others;- Studies that explore host-virus interactions, immunology and immune evasion;- Vaccines and disease control strategies.