About this Research Topic
This Research Topic is the second volume of the 'Recent Advances in Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) in Heart-Related Diseases.' Please find the first volume here.
In recent years, the interaction between subcellular organelles has attracted great attention. Mitochondria and endoplasmic reticulum (ER) are essential for maintaining cardiomyocyte function and cardiac development. Damage to either organelle can lead to serious heart-related diseases. Interestingly, a large number of studies have confirmed the existence of vesicle transport and signal transduction between the two subcellular organelles, and their close interaction has also been confirmed. Mitochondria-associated ER membranes (MAMs), also known as mitochondria-ER contact sites (MERCs), are a highly dynamic and tightly connected portion of the ER and mitochondria. MAMs are associated with a variety of cellular functions, such as calcium homeostasis, lipid metabolism, ROS, autophagy, apoptosis, ferroptosis, and inflammation, and abnormalities of these factors often contribute to the progression of heart-related diseases. MAM-associated proteins contribute to the formation of MAM or regulation of several cellular functions, and abnormal expression or mutation of these proteins often leads to the initiation and development of heart-related diseases.
It is important to understand the roles of MAM-associated proteins to identify novel therapeutic targets for the prevention or treatment of heart-related diseases. Based on this, exploring the regulatory mechanisms of MAM-related proteins and their specific activators or inhibitors that possessed the potential to directly affect the pathogenesis of heart-related diseases, and this field of studies are of great significance for combating these diseases.
In this Research Topic, we would like to explore the important role of MAMs and the MAM-associated proteins in cardiac development, uncover the cellular and physiological mechanisms linking MAMs and heart-related diseases, as well as the pathophysiological consequences of heart-related diseases caused by the defects of MAM-associated proteins. We encourage studies that provide new evidence and insight of the effects of MAMs and MAM-associated proteins on heart-related diseases. In addition, studies are welcome that focus on screening new inhibitors or activators of MAM-associated proteins and exploring the possibility of these inhibitors in combating heart-related diseases. Several new techniques, including multidimensional omics, ultra-high resolution and living cell imaging, are worth using to uncover the association between MAMs and heart-related diseases.
All papers on the following research themes are welcome:
1) Roles of MAMs and MAM-associated proteins in heart development.
2) New mechanisms underlying MAM-associated proteins affecting the pathology of heart-related diseases.
3) Treatment effects of MAM-associated protein inhibitors or activators on heart-related diseases.
4) The role of communication and interaction between mitochondria and endoplasmic reticulum in heart-related diseases.
5) Effects of MAM-related cellular processes on the progression of heart-related diseases.
6) New mechanisms or functions of MAMs in heart-related diseases.
7) Discovery of new MAM-associated proteins and their roles and mechanisms in MAM.
8) Application of new techniques for the detection of MAMs in the heart.
9) New effects of traditional treatments for heart-related diseases on MAMs.
In recent years, the interaction between subcellular organelles has attracted great attention. Mitochondria and endoplasmic reticulum (ER) are essential for maintaining cardiomyocyte function and cardiac development. Damage to either organelle can lead to serious heart-related diseases. Interestingly, a large number of studies have confirmed the existence of vesicle transport and signal transduction between the two subcellular organelles, and their close interaction has also been confirmed. Mitochondria-associated ER membranes (MAMs), also known as mitochondria-ER contact sites (MERCs), are a highly dynamic and tightly connected portion of the ER and mitochondria. MAMs are associated with a variety of cellular functions, such as calcium homeostasis, lipid metabolism, ROS, autophagy, apoptosis, ferroptosis, and inflammation, and abnormalities of these factors often contribute to the progression of heart-related diseases. MAM-associated proteins contribute to the formation of MAM or regulation of several cellular functions, and abnormal expression or mutation of these proteins often leads to the initiation and development of heart-related diseases.
It is important to understand the roles of MAM-associated proteins to identify novel therapeutic targets for the prevention or treatment of heart-related diseases. Based on this, exploring the regulatory mechanisms of MAM-related proteins and their specific activators or inhibitors that possessed the potential to directly affect the pathogenesis of heart-related diseases, and this field of studies are of great significance for combating these diseases.
In this Research Topic, we would like to explore the important role of MAMs and the MAM-associated proteins in cardiac development, uncover the cellular and physiological mechanisms linking MAMs and heart-related diseases, as well as the pathophysiological consequences of heart-related diseases caused by the defects of MAM-associated proteins. We encourage studies that provide new evidence and insight of the effects of MAMs and MAM-associated proteins on heart-related diseases. In addition, studies are welcome that focus on screening new inhibitors or activators of MAM-associated proteins and exploring the possibility of these inhibitors in combating heart-related diseases. Several new techniques, including multidimensional omics, ultra-high resolution and living cell imaging, are worth using to uncover the association between MAMs and heart-related diseases.
All papers on the following research themes are welcome:
1) Roles of MAMs and MAM-associated proteins in heart development.
2) New mechanisms underlying MAM-associated proteins affecting the pathology of heart-related diseases.
3) Treatment effects of MAM-associated protein inhibitors or activators on heart-related diseases.
4) The role of communication and interaction between mitochondria and endoplasmic reticulum in heart-related diseases.
5) Effects of MAM-related cellular processes on the progression of heart-related diseases.
6) New mechanisms or functions of MAMs in heart-related diseases.
7) Discovery of new MAM-associated proteins and their roles and mechanisms in MAM.
8) Application of new techniques for the detection of MAMs in the heart.
9) New effects of traditional treatments for heart-related diseases on MAMs.
Keywords: Mitochondria, Endoplasmic reticulum, Mitochondria-associated endoplasmic reticulum membranes (MAMs), Heart-related diseases
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