The Trypanosomatidae are an important group of obligatory unicellular parasites which contain species known to the cause neglected tropical diseases in humans: leishmaniasis, human African sleeping sickness (HAT) and Chagas disease. Some of these parasites have a wide geographic distribution globally and have adapted in response to specific host genetics and environmental pressures. Importantly, these parasites have complex lifecycles and are transmitted to humans via insect bites; and often have other mammals which are reservoirs for the parasites. Given this, these diseases are broadly considered a one health problem. Host-parasite interactions are complex, and it remains uncertain why or how some patients respond better than others to the infection with Trypanosomatidae. Moreover, despite a concerted research effort around the world, the immune components responsible for diversity of disease specific symptoms and outcomes are unknown.
Three important neglected diseases are caused by Trypanosomatidae: leishmaniasis, human African sleeping sickness (HAT) and Chagas disease. Among them, there are more than 7 million infected people around the world causing significant public health burden. These diseases are not easily be eradicated since reservoir animals are able to maintain the parasites independently as a source of zoonotic infection. Scientific advances have focused on early diagnostics, vaccines, treatments, and vector control. Here, this research topic aims to compile the most recent advances in immunological biomarkers that can support a greater understanding of host immune responses to leishmaniasis, human African sleeping sickness (HAT) and Chagas disease. In particular, the research topic focuses on immunological biomarkers which may aid in early diagnosis, diagnosis differentiation, prophylaxis and vaccinology. This can further consolidate current knowledge and facilitate the progress towards the elimination of these neglected tropical diseases.
This Research Topic accepts Original Research, Systematic Review, Methods, Review, Clinical Trial, Perspective. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• host immune responses to Trypanossomatidae
• immunological biomarkers in Trypanossomatidae diseases (mainly human) for early diagnosis and diagnosis differentiation
• Immunological biomarkers in Trypanossomatidae diseases (mainly human) for prophylaxis, including One health
• Immunological biomarkers in Trypanossomatidae diseases (mainly human) for vaccinology
• Immunological biomarkers in Trypanossomatidae diseases (mainly human) for immune competence and mechanisms of parasite survival
The Topic Editors declare no competing interests with regard to the Research Topic subject.
The Trypanosomatidae are an important group of obligatory unicellular parasites which contain species known to the cause neglected tropical diseases in humans: leishmaniasis, human African sleeping sickness (HAT) and Chagas disease. Some of these parasites have a wide geographic distribution globally and have adapted in response to specific host genetics and environmental pressures. Importantly, these parasites have complex lifecycles and are transmitted to humans via insect bites; and often have other mammals which are reservoirs for the parasites. Given this, these diseases are broadly considered a one health problem. Host-parasite interactions are complex, and it remains uncertain why or how some patients respond better than others to the infection with Trypanosomatidae. Moreover, despite a concerted research effort around the world, the immune components responsible for diversity of disease specific symptoms and outcomes are unknown.
Three important neglected diseases are caused by Trypanosomatidae: leishmaniasis, human African sleeping sickness (HAT) and Chagas disease. Among them, there are more than 7 million infected people around the world causing significant public health burden. These diseases are not easily be eradicated since reservoir animals are able to maintain the parasites independently as a source of zoonotic infection. Scientific advances have focused on early diagnostics, vaccines, treatments, and vector control. Here, this research topic aims to compile the most recent advances in immunological biomarkers that can support a greater understanding of host immune responses to leishmaniasis, human African sleeping sickness (HAT) and Chagas disease. In particular, the research topic focuses on immunological biomarkers which may aid in early diagnosis, diagnosis differentiation, prophylaxis and vaccinology. This can further consolidate current knowledge and facilitate the progress towards the elimination of these neglected tropical diseases.
This Research Topic accepts Original Research, Systematic Review, Methods, Review, Clinical Trial, Perspective. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• host immune responses to Trypanossomatidae
• immunological biomarkers in Trypanossomatidae diseases (mainly human) for early diagnosis and diagnosis differentiation
• Immunological biomarkers in Trypanossomatidae diseases (mainly human) for prophylaxis, including One health
• Immunological biomarkers in Trypanossomatidae diseases (mainly human) for vaccinology
• Immunological biomarkers in Trypanossomatidae diseases (mainly human) for immune competence and mechanisms of parasite survival
The Topic Editors declare no competing interests with regard to the Research Topic subject.
