Autophagy is a highly conserved cellular process that plays a crucial role in maintaining cellular homeostasis by clearing out damaged or unnecessary cellular components. It involves the formation of double-membrane vesicles, known as autophagosomes, which engulf cytoplasmic cargo and deliver it to the lysosomes through forming autolysosomes for degradation and recycling.
Autophagy has emerged as a key player in a variety of physiological processes such as cellular homeostasis, aging, metabolism, and pregnancy. The dysregulation of autophagy has been implicated in the pathogenesis of numerous disorders, including cancer, neurodegeneration, perinatal brain injury, infectious diseases, adverse pregnancy outcomes, renal diseases, cardiovascular diseases, diabetes, obesity, etc., highlighting the importance of understanding the underlying mechanisms of this process.
This Research Topic aims to provide a comprehensive overview of the current state of knowledge regarding autophagy, from the molecular mechanisms underlying its regulation to its implications in various disease contexts. The articles included in this issue will cover a wide range of topics, including the role of autophagy in cellular metabolism, the crosstalk between autophagy and other cellular processes, and the therapeutic potential of targeting autophagy in disease.
Overall, this Research Topic represents a timely and important contribution to the growing body of literature on autophagy and its implications in health and disease. We hope that the articles included in this Research Topic will stimulate further research in this field and ultimately lead to the development of novel therapeutic strategies for a variety of human disorders.
Autophagy is a highly conserved cellular process that plays a crucial role in maintaining cellular homeostasis by clearing out damaged or unnecessary cellular components. It involves the formation of double-membrane vesicles, known as autophagosomes, which engulf cytoplasmic cargo and deliver it to the lysosomes through forming autolysosomes for degradation and recycling.
Autophagy has emerged as a key player in a variety of physiological processes such as cellular homeostasis, aging, metabolism, and pregnancy. The dysregulation of autophagy has been implicated in the pathogenesis of numerous disorders, including cancer, neurodegeneration, perinatal brain injury, infectious diseases, adverse pregnancy outcomes, renal diseases, cardiovascular diseases, diabetes, obesity, etc., highlighting the importance of understanding the underlying mechanisms of this process.
This Research Topic aims to provide a comprehensive overview of the current state of knowledge regarding autophagy, from the molecular mechanisms underlying its regulation to its implications in various disease contexts. The articles included in this issue will cover a wide range of topics, including the role of autophagy in cellular metabolism, the crosstalk between autophagy and other cellular processes, and the therapeutic potential of targeting autophagy in disease.
Overall, this Research Topic represents a timely and important contribution to the growing body of literature on autophagy and its implications in health and disease. We hope that the articles included in this Research Topic will stimulate further research in this field and ultimately lead to the development of novel therapeutic strategies for a variety of human disorders.
