The human body gets its balance and homeostasis from the harbored useful microorganisms. Indeed, the human fetus experiences the first microbial exposure within his/her mother’s body. During the post-partum period, an infant gets formed to be inhabited by different types of useful microorganisms, e.g., archaea, bacteria, fungi, and viruses, collectively known as the microbiota. In particular, the evolution of the gut microbiota throughout life appears to play a pivotal role in both health and disease. On the one hand, metabolic regulation, homeostasis, and a strong immune system depend on gut microbiota balance or eubiosis. On the other hand, gut microbiota dysregulation or dysbiosis is observed in many diseases like diabetes, cancers, autoimmune diseases, inflammatory bowel disorders, atherosclerotic cardiovascular diseases, kidney diseases, neurological disorders, e.g., Alzheimer’s and Parkinson’s diseases, mental health disorders, etc. Interestingly, environmental factors and genetics are involved. Therefore, the interconnection between host-microbiota-environments is a fascinating and emerging area of research to understand health and disease.
As aforementioned, the appearance of dysbiosis or eubiosis directly affects the human body’s status. This research topic aims to involve all the cases associated with gut microbiome composition, environmental factors (such as diet and nutrients), genetics and the related consequences whether positive or negative in both men and women. Hence, a wide range of items are regarded in the present Research Topic.
? Eubiosis: Health and homeostasis condition
Archaea
Bacteria
Fungi
Viruses
Predisposing factors (maternal microbiome, delivery condition, biomass index (BMI), diet, nutrition etc.)
Immune system maturity
Neonates
Infants
Children
Young adults
Adults
Genetics
Epigenetics
Females and Males
? Gut microbiome and Metabolic regulation
Nutrients metabolisms
Risk and environmental factors
Sex-related factors
Genetics
Epigenetics
Diseases
? Dysbiosis: Diseases and negative consequences
Atherosclerotic cardiovascular diseases
Autoimmune diseases
Bowel disorders
Cancers
Diabetes
Kidney diseases
Mental health disorders e.g., stress, psychotic disorders and diseases
Neurological disorders e.g., Alzheimer’s and Parkinson’s diseases
Obesity
Sex-related factors
Neonates
Infants
Children
Young adults
Adults
Genetics
Epigenetics
? Gut microbiome and Immune network interactions
Innate immune cells
Cytokines, chemokines, Interleukins and the related signaling pathways
Receptors including Pattern Recognition Receptors (PRRs) e.g., Toll-like receptors (TLRs) and signaling pathways
Adaptive immune cells including B- and T cells
Non-immune cells
The human body gets its balance and homeostasis from the harbored useful microorganisms. Indeed, the human fetus experiences the first microbial exposure within his/her mother’s body. During the post-partum period, an infant gets formed to be inhabited by different types of useful microorganisms, e.g., archaea, bacteria, fungi, and viruses, collectively known as the microbiota. In particular, the evolution of the gut microbiota throughout life appears to play a pivotal role in both health and disease. On the one hand, metabolic regulation, homeostasis, and a strong immune system depend on gut microbiota balance or eubiosis. On the other hand, gut microbiota dysregulation or dysbiosis is observed in many diseases like diabetes, cancers, autoimmune diseases, inflammatory bowel disorders, atherosclerotic cardiovascular diseases, kidney diseases, neurological disorders, e.g., Alzheimer’s and Parkinson’s diseases, mental health disorders, etc. Interestingly, environmental factors and genetics are involved. Therefore, the interconnection between host-microbiota-environments is a fascinating and emerging area of research to understand health and disease.
As aforementioned, the appearance of dysbiosis or eubiosis directly affects the human body’s status. This research topic aims to involve all the cases associated with gut microbiome composition, environmental factors (such as diet and nutrients), genetics and the related consequences whether positive or negative in both men and women. Hence, a wide range of items are regarded in the present Research Topic.
? Eubiosis: Health and homeostasis condition
Archaea
Bacteria
Fungi
Viruses
Predisposing factors (maternal microbiome, delivery condition, biomass index (BMI), diet, nutrition etc.)
Immune system maturity
Neonates
Infants
Children
Young adults
Adults
Genetics
Epigenetics
Females and Males
? Gut microbiome and Metabolic regulation
Nutrients metabolisms
Risk and environmental factors
Sex-related factors
Genetics
Epigenetics
Diseases
? Dysbiosis: Diseases and negative consequences
Atherosclerotic cardiovascular diseases
Autoimmune diseases
Bowel disorders
Cancers
Diabetes
Kidney diseases
Mental health disorders e.g., stress, psychotic disorders and diseases
Neurological disorders e.g., Alzheimer’s and Parkinson’s diseases
Obesity
Sex-related factors
Neonates
Infants
Children
Young adults
Adults
Genetics
Epigenetics
? Gut microbiome and Immune network interactions
Innate immune cells
Cytokines, chemokines, Interleukins and the related signaling pathways
Receptors including Pattern Recognition Receptors (PRRs) e.g., Toll-like receptors (TLRs) and signaling pathways
Adaptive immune cells including B- and T cells
Non-immune cells
