PI3K signalling

154K

views

28

authors

12

articles

PI3K signalling

154K

views

28

authors

12

articles

Editorial

03 November 2014

PI3K Signaling in B Cell and T Cell Biology

Klaus Okkenhaug

,

Martin Turner

and

Michael R. Gold

10,071 views

25 citations

Editors

3

Klaus Okkenhaug

University of Cambridge

Babraham Institute (BBSRC)

University of British Columbia

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The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. Most recently, PI3K inhibitors have entered clinical trials, showing particular efficacy in B cell lymphoma. Trials in autoimmune and inflammatory diseases are also underway or being planned.

This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.

The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. Most recently, PI3K inhibitors have entered clinical trials, showing particular efficacy in B cell lymphoma. Trials in autoimmune and inflammatory diseases are also underway or being planned.

This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.

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Editors

Klaus Okkenhaug

University of Cambridge

Babraham Institute (BBSRC)

University of British Columbia

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Frontiers in Immunology

B Cell Biology, T Cell Biology

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