The nervous system rapidly senses environmental stimulations and transmits these signals to immune cells via neurotransmitters and neuropeptides to modulate responses systemically. It has a footprint in every organ, especially barrier sites like the skin and gastrointestinal tract.
Epithelial barrier cells cover the entire body surface, and their exposure to environmental pathogens and allergens triggers the release of proinflammatory cytokines, which induce innate and adaptive immune responses. Activated immune cells produce inflammatory mediators, such as pro-inflammatory cytokines, nerve growth factors, prostaglandins, and histamine, which directly stimulate peripheral nerve endings and enhance neuronal functions at the site of inflammation. In addition, activated neuronal terminals release various neuropeptides such as substance P, neurokinin A, vasoactive intestinal peptide (VIP), and calcitonin gene-related peptide (CGRP). They respond to neuronal signals and regulate immune cell function through neurotransmitter receptors on the surface of immune cells. This reflects the close interaction between the nervous system and the immune system.
Research on neuroimmune crosstalk has become an active field in recent years. This article collection aims to provide an up-to-date review of the role of neuroimmune interactions in inflammatory or allergic diseases and encourage submissions of Original Research articles. Subtopics will cover but not be limited to the following:
? Shared anatomical localization of neurons in surrounding tissues with immune cells including dendritic cells (DCs), macrophages, mast cells, etc.
? Identifying neuro-mediator receptor signaling pathways of neuroimmune communication.
? Explore the potential of neuroimmune communication for therapy targeting and design.
Note: Some important diseases that may be covered in this Research Topic include psoriasis, rheumatoid arthritis, lupus, atopic dermatitis, inflammatory bowel disease, etc.
The nervous system rapidly senses environmental stimulations and transmits these signals to immune cells via neurotransmitters and neuropeptides to modulate responses systemically. It has a footprint in every organ, especially barrier sites like the skin and gastrointestinal tract.
Epithelial barrier cells cover the entire body surface, and their exposure to environmental pathogens and allergens triggers the release of proinflammatory cytokines, which induce innate and adaptive immune responses. Activated immune cells produce inflammatory mediators, such as pro-inflammatory cytokines, nerve growth factors, prostaglandins, and histamine, which directly stimulate peripheral nerve endings and enhance neuronal functions at the site of inflammation. In addition, activated neuronal terminals release various neuropeptides such as substance P, neurokinin A, vasoactive intestinal peptide (VIP), and calcitonin gene-related peptide (CGRP). They respond to neuronal signals and regulate immune cell function through neurotransmitter receptors on the surface of immune cells. This reflects the close interaction between the nervous system and the immune system.
Research on neuroimmune crosstalk has become an active field in recent years. This article collection aims to provide an up-to-date review of the role of neuroimmune interactions in inflammatory or allergic diseases and encourage submissions of Original Research articles. Subtopics will cover but not be limited to the following:
? Shared anatomical localization of neurons in surrounding tissues with immune cells including dendritic cells (DCs), macrophages, mast cells, etc.
? Identifying neuro-mediator receptor signaling pathways of neuroimmune communication.
? Explore the potential of neuroimmune communication for therapy targeting and design.
Note: Some important diseases that may be covered in this Research Topic include psoriasis, rheumatoid arthritis, lupus, atopic dermatitis, inflammatory bowel disease, etc.
