Hormones and Neural Aging: Lessons from Experimental Models

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63

authors

12

articles

Hormones and Neural Aging: Lessons from Experimental Models

142K

views

63

authors

12

articles

Editorial

15 November 2018

Editorial: Hormones and Neural Aging: Lessons From Experimental Models

Isabel Varela-Nieto

,

Julie A. Chowen

and

Luis Miguel García-Segura

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Editors

3

Isabel Varela-Nieto

Spanish National Research Council (CSIC)

Luis Miguel Garcia-Segura

Spanish National Research Council (CSIC)

Julie A Chowen

Niño Jesús University Children's Hospital

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The study of aging by using experimental models offers an opportunity to understand human physiopathology, which complements clinical and epidemiological studies.

The relationship between the hormonal status and neural aging has been studied in different contexts, from metabolism to reproduction. Neural aging is associated with modifications in the levels of different peripheral neuroprotective hormones, as it is also affected the sensitivity of neurons and glial cells to respond to peripheral metabolic signals. In turn, neural aging affects the control exerted by the hypothalamus on peripheral endocrine glands and body metabolism. Therefore, the feed-back loops between the brain and the body are progressively altered during the aging process, contributing to neural dysfunction.

Here, we propose to connect these studies with the current knowledge on the neurodegeneration of brain and sensory systems that takes place alongside aging. Molecular pathways implicated in the decreased cell renewal, cell senescence and cell death, as well as potential strategies to promote healthy brain aging and rejuvenation will be presented.

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Editors

Isabel Varela-Nieto

Spanish National Research Council (CSIC)

Luis Miguel Garcia-Segura

Spanish National Research Council (CSIC)

Julie A Chowen

Niño Jesús University Children's Hospital

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141,989 Total views

113,215 Article views

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Published In

Frontiers in Aging Neuroscience

Neuroinflammation and Neuropathy, Alzheimer's Disease and Related Dementias, Neurocognitive Aging and Behavior, Cellular and Molecular Mechanisms of Brain-aging, Parkinson’s Disease and Aging-related Movement Disorders, Aging Neuroscience Archive

Frontiers in Endocrinology

Neuroendocrine Science

Frontiers in Molecular Neuroscience

Molecular Neuroscience Archive, Molecular Signalling and Pathways, Neuroplasticity and Development

Frontiers in Neuroscience

Neuroendocrine Science

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