Chronic pain, characterized by persistent or recurrent pain lasting for an extended period of time, is a universal problem affecting millions of individuals worldwide and often results in significant disability and reduced quality of life. Pharmacological interventions have been the traditional approach for chronic pain management, but often come with significant side effects that can limit their effectiveness. Therefore, the development of novel interventions is necessary to improve patient outcomes and reduce the burden of chronic pain. Non-pharmacological interventions, such as exercise and cognitive-behavioral therapy, have been shown to display lower side effects and have gained interest as alternative approaches. However, the underlying molecular mechanisms, and their efficacy in chronic pain control in animal models, are not fully understood.This Research Topic aims to provide a comprehensive overview of pharmacological and non-pharmacological interventions against the development of chronic pain using animal models. The primary goal is to explore the molecular mechanisms of these interventions, including their effects on pain sensitivity and associated behaviors including: anxiety, depression, and cognitive abilities. In addition, this article collection aims to highlight recent advances in the development of novel interventions against chronic pain and identify key areas where further research is needed. By bringing together key researchers in this field, this Research Topic seeks to promote a multidisciplinary approach to chronic pain research and identify promising avenues for potential treatments.We aim to cover a wide range of topics related to pharmacological and non-pharmacological interventions for chronic pain management in animal models. Potential areas of research may include, but are not limited to, the following:- Molecular mechanisms underlying the effects of pharmacological and non-pharmacological interventions on pain perception and associated behaviors in animal models.- The identification of molecular targets against chronic pain.- Comparative analysis of the efficacy and side effects of pharmacological and non-pharmacological interventions for chronic pain management in animal models.- The development of novel pharmacological and non-pharmacological interventions for chronic pain management in animal models.- The translation of findings from animal models to clinical settings, including the identification of potential therapeutic targets for chronic pain management in humans.We will not, however, be accepting articles investigating acupuncture as a non-pharmacological intervention for chronic pain.This collection will be of interest to a wide range of researchers and clinicians, including neuroscientists, pharmacologists, and clinicians specializing in pain management. By bringing together diverse perspectives and expertise, this Research Topic aims to advance our understanding of chronic pain and to identify novel interventions for its management.
Chronic pain, characterized by persistent or recurrent pain lasting for an extended period of time, is a universal problem affecting millions of individuals worldwide and often results in significant disability and reduced quality of life. Pharmacological interventions have been the traditional approach for chronic pain management, but often come with significant side effects that can limit their effectiveness. Therefore, the development of novel interventions is necessary to improve patient outcomes and reduce the burden of chronic pain. Non-pharmacological interventions, such as exercise and cognitive-behavioral therapy, have been shown to display lower side effects and have gained interest as alternative approaches. However, the underlying molecular mechanisms, and their efficacy in chronic pain control in animal models, are not fully understood.This Research Topic aims to provide a comprehensive overview of pharmacological and non-pharmacological interventions against the development of chronic pain using animal models. The primary goal is to explore the molecular mechanisms of these interventions, including their effects on pain sensitivity and associated behaviors including: anxiety, depression, and cognitive abilities. In addition, this article collection aims to highlight recent advances in the development of novel interventions against chronic pain and identify key areas where further research is needed. By bringing together key researchers in this field, this Research Topic seeks to promote a multidisciplinary approach to chronic pain research and identify promising avenues for potential treatments.We aim to cover a wide range of topics related to pharmacological and non-pharmacological interventions for chronic pain management in animal models. Potential areas of research may include, but are not limited to, the following:- Molecular mechanisms underlying the effects of pharmacological and non-pharmacological interventions on pain perception and associated behaviors in animal models.- The identification of molecular targets against chronic pain.- Comparative analysis of the efficacy and side effects of pharmacological and non-pharmacological interventions for chronic pain management in animal models.- The development of novel pharmacological and non-pharmacological interventions for chronic pain management in animal models.- The translation of findings from animal models to clinical settings, including the identification of potential therapeutic targets for chronic pain management in humans.We will not, however, be accepting articles investigating acupuncture as a non-pharmacological intervention for chronic pain.This collection will be of interest to a wide range of researchers and clinicians, including neuroscientists, pharmacologists, and clinicians specializing in pain management. By bringing together diverse perspectives and expertise, this Research Topic aims to advance our understanding of chronic pain and to identify novel interventions for its management.