About this Research Topic
The circadian clock is an intrinsic adaptive mechanism regulated by day-night cycles, enabling organisms to anticipate environmental changes. This clock can be reset by stimuli known as zeitgebers, aligning circadian rhythms with the 24-hour cycle. Disruptions to the circadian clock can lead to various pathologies, including cardiovascular and metabolic diseases.
Understanding the interplay between the circadian clock and cardiovascular health is crucial for developing chrono-pharmacological strategies to address these interconnected conditions.
Cardiovascular and metabolic diseases are a leading cause of global mortality, encompassing conditions such as obesity, insulin resistance, and atherosclerosis. These diseases can disrupt the circadian clock, further impacting cardiovascular health. By addressing shared risk factors and focusing on the circadian clock, comprehensive approaches can potentially improve outcomes for these interconnected health conditions.
Furthermore, as the global population ages, cancer rates continue to climb. As cancer treatment advances, more survivors are experiencing long-term complications such as cardiotoxicity. Cardiotoxicity, characterized by heart damage and dysfunction, significantly contributes to co-morbidity and mortality in cancer treatments. Certain chemotherapies and targeted anti-cancer medications such as doxorubicin, trastuzumab, sunitinib, imatinib, ponatinib, and radiotherapy, have been associated with cardiotoxicity. Understanding the mechanisms underlying cancer therapy-induced cardiotoxicity is crucial for developing effective prevention and treatment strategies.
Epidemiological studies have shown that adverse cardiac events tend to occur in the early hours of the morning. Utilizing chrono-pharmacology, where drugs are delivered in accordance with an individual's circadian rhythms, holds great potential for developing personalized treatment protocols. By understanding the precise functions of biological clocks in cardiovascular and metabolic systems, we can develop targeted chrono-pharmacological interventions.
In this Research Topic, we encourage our colleagues to present their original mechanistic, pre-clinical, or clinical research articles, reviews, mini-reviews, methods, and commentaries on the following sub-topics related but not limited to cardiovascular and metabolic chrono-biomedicine:
- Molecular and genetic basis of circadian rhythms in the cardiovascular system at the cellular level.
- Association between disturbance of the circadian clock and onset of cardiovascular pathologies.
- Circadian-based interventions for improving cardiovascular health (chronotherapeutic and chrono-nutritional strategies).
- Correlation between cardiometabolic risks, chronotypes, and therapeutic targets for improving cardiometabolic conditions.
- Therapeutic benefits of time-dependent physical activity, food intake, and sleep on cardiometabolic health.
- Molecular changes and circadian adaptation in skeletal muscle and cardiovascular health.
- Interplay between circadian rhythm and cardiovascular functions and potential drug targets.
- Mitigating cardiometabolic risks through lifestyle interventions and chronopharmacologic interventions.
- Pharmacogenomics and circadian rhythms as modulators of cardiovascular drug-drug interactions.
- Comprehensive approaches addressing cardiovascular disease, obesity and cancer through the circadian clock.
- Impact of the circadian clock on chemotherapy-induced cardiotoxicity and potential interventions.
Understanding the interplay between the circadian clock and cardiovascular health is crucial for developing chrono-pharmacological strategies to address these interconnected conditions.
Cardiovascular and metabolic diseases are a leading cause of global mortality, encompassing conditions such as obesity, insulin resistance, and atherosclerosis. These diseases can disrupt the circadian clock, further impacting cardiovascular health. By addressing shared risk factors and focusing on the circadian clock, comprehensive approaches can potentially improve outcomes for these interconnected health conditions.
Furthermore, as the global population ages, cancer rates continue to climb. As cancer treatment advances, more survivors are experiencing long-term complications such as cardiotoxicity. Cardiotoxicity, characterized by heart damage and dysfunction, significantly contributes to co-morbidity and mortality in cancer treatments. Certain chemotherapies and targeted anti-cancer medications such as doxorubicin, trastuzumab, sunitinib, imatinib, ponatinib, and radiotherapy, have been associated with cardiotoxicity. Understanding the mechanisms underlying cancer therapy-induced cardiotoxicity is crucial for developing effective prevention and treatment strategies.
Epidemiological studies have shown that adverse cardiac events tend to occur in the early hours of the morning. Utilizing chrono-pharmacology, where drugs are delivered in accordance with an individual's circadian rhythms, holds great potential for developing personalized treatment protocols. By understanding the precise functions of biological clocks in cardiovascular and metabolic systems, we can develop targeted chrono-pharmacological interventions.
In this Research Topic, we encourage our colleagues to present their original mechanistic, pre-clinical, or clinical research articles, reviews, mini-reviews, methods, and commentaries on the following sub-topics related but not limited to cardiovascular and metabolic chrono-biomedicine:
- Molecular and genetic basis of circadian rhythms in the cardiovascular system at the cellular level.
- Association between disturbance of the circadian clock and onset of cardiovascular pathologies.
- Circadian-based interventions for improving cardiovascular health (chronotherapeutic and chrono-nutritional strategies).
- Correlation between cardiometabolic risks, chronotypes, and therapeutic targets for improving cardiometabolic conditions.
- Therapeutic benefits of time-dependent physical activity, food intake, and sleep on cardiometabolic health.
- Molecular changes and circadian adaptation in skeletal muscle and cardiovascular health.
- Interplay between circadian rhythm and cardiovascular functions and potential drug targets.
- Mitigating cardiometabolic risks through lifestyle interventions and chronopharmacologic interventions.
- Pharmacogenomics and circadian rhythms as modulators of cardiovascular drug-drug interactions.
- Comprehensive approaches addressing cardiovascular disease, obesity and cancer through the circadian clock.
- Impact of the circadian clock on chemotherapy-induced cardiotoxicity and potential interventions.
Keywords: Circadian rhythms, Melatonin, Chronopharmacology, Chronotherapy, Circadian disruption, Biological rhythms, Cardiovascular diseases, Metabolic imbalance
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