Immunity to Human Fungal Pathogens: Mechanisms of Host Recognition, Protection, Pathology, and Fungal Interference

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Editorial

15 October 2018

Editorial: Immunity to Human Fungal Pathogens: Mechanisms of Host Recognition, Protection, Pathology, and Fungal Interference

Steven P. Templeton

,

Amariliz Rivera

,

Bernard Hube

and

Ilse D. Jacobsen

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13 citations

Editors

4

Steven Templeton

Indiana University School of Medicine-Terre Haute

Amariliz Rivera

Center for Immunity and Inflammation, New Jersey Medical School, Rutgers, The State University of New Jersey

Bernhard Hube

Leibniz Institute for Natural Product Research and Infection Biology

Ilse Denise Jacobsen

Leibniz Institute for Natural Product Research and Infection Biology

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Fungi are found in virtually every environment, and comprise a significant portion of the normal microflora of healthy individuals. Some species of fungi are aeroallergen sources capable of inducing sensitization and causing exacerbation of asthma and respiratory allergy. Others are transmissible between hosts and may cause no symptoms in healthy individuals. However, immune suppressed individuals may develop invasive disease marked by tissue invasion with a potential for widespread dissemination. Existing therapies for patients consist of antifungal drugs, yet these require prolonged administration with the possibility of adverse side effects, and may be rendered ineffective by the emergence of antifungal-resistant strains. It is therefore of interest to increase our understanding of host-pathogen interactions in order to facilitate the development of new therapies for individuals suffering from fungal infection and disease. These early interactions are shaped by an array of constituent and secreted factors that stimulate or inhibit host immune responses toward protective or detrimental immunity. Likewise, an array of preformed factors and tissue-resident cells provide early protection from fungal infection and provide extracellular signals that result in localized recruitment of inflammatory cells and determine the character of subsequent adaptive antifungal immunity.

The aim of this research topic is to explore the host and fungal pathways that program innate and adaptive immunity and the immune cells, molecules, and regulatory pathways that comprise protective or detrimental responses to fungal exposure or infection.

We welcome researchers to submit reviews, opinions, or original research focusing on antifungal immunity in humans and in experimental models. We hope that the results of these efforts will provide a benchmark for further advances and improved antifungal therapies.

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Editors

Steven Templeton

Indiana University School of Medicine-Terre Haute

Amariliz Rivera

Center for Immunity and Inflammation, New Jersey Medical School, Rutgers, The State University of New Jersey

Bernhard Hube

Leibniz Institute for Natural Product Research and Infection Biology

Ilse Denise Jacobsen

Leibniz Institute for Natural Product Research and Infection Biology

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353,916 Total views

276,075 Article views

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Published In

Frontiers in Immunology

Microbial Immunology

Frontiers in Microbiology

Microbial Immunology

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