In tumor tissue, both tumor and non-tumor cells compete for nutrients and excrete bioactive metabolites, which together shape hypoxia, low pH (acidosis), and nutrient-deficient tumor metabolic microenvironment (TMME). As an important way to adapt to environmental stress, metabolic reprogramming has been observed in both tumor cells and immune cells. However, due to their metabolic heterogeneity, TMME seems to be a near-death wasteland for anti-tumor immune cells but a happy-go-lucky palace for tumor cells and immunosuppressive cells. For example, the glucose up-taken and glycolysis are enhanced in tumor cells and some immunosuppressive cells (TAMs, MDSCs.et.al), which could reinforce their survival in nutrient-deficient TMME. But the subsequent glucose deprivation and lactate accumulation in TMME will severely impede CD8+T cell activation and survival. In the meantime, taking lactates as fuel makes Treg cells fit the acidosis TME better.
Therefore, metabolism dysregulation and reprogramming may be important causes of immuno-suppression and immune escape in tumors, which may lead to immunotherapy resistance. Gaining a deep understanding of the crosstalk between TME and immune cells metabolism or function reprogramming could offer new directions in the manipulation of anti-tumor immune responses.
This Research Topic is centered around all aspects of the metabolism characteristics and crosstalk between tumor metabolism and immune cells in TME. We aim to compile a collection of Original Research and Review articles to explore novel metabolic checkpoints and therapeutics.
Submissions may focus on, but are not limited to, the following subtopics:
1. Insights into the metabolic heterogeneity of immune cells in TME;
2. Crosstalk between tumor immune resistance and metabolism in TME;
3. Diagnostic and therapeutic strategies based on metabolism characteristics of TME;
4. The way of metabolism reprogramming to regulate immunotherapy (ICBs, CAR-T, etc.);
5. Novel cancer metabolism therapy targets mining from big data by interdisciplinary strategies.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
In tumor tissue, both tumor and non-tumor cells compete for nutrients and excrete bioactive metabolites, which together shape hypoxia, low pH (acidosis), and nutrient-deficient tumor metabolic microenvironment (TMME). As an important way to adapt to environmental stress, metabolic reprogramming has been observed in both tumor cells and immune cells. However, due to their metabolic heterogeneity, TMME seems to be a near-death wasteland for anti-tumor immune cells but a happy-go-lucky palace for tumor cells and immunosuppressive cells. For example, the glucose up-taken and glycolysis are enhanced in tumor cells and some immunosuppressive cells (TAMs, MDSCs.et.al), which could reinforce their survival in nutrient-deficient TMME. But the subsequent glucose deprivation and lactate accumulation in TMME will severely impede CD8+T cell activation and survival. In the meantime, taking lactates as fuel makes Treg cells fit the acidosis TME better.
Therefore, metabolism dysregulation and reprogramming may be important causes of immuno-suppression and immune escape in tumors, which may lead to immunotherapy resistance. Gaining a deep understanding of the crosstalk between TME and immune cells metabolism or function reprogramming could offer new directions in the manipulation of anti-tumor immune responses.
This Research Topic is centered around all aspects of the metabolism characteristics and crosstalk between tumor metabolism and immune cells in TME. We aim to compile a collection of Original Research and Review articles to explore novel metabolic checkpoints and therapeutics.
Submissions may focus on, but are not limited to, the following subtopics:
1. Insights into the metabolic heterogeneity of immune cells in TME;
2. Crosstalk between tumor immune resistance and metabolism in TME;
3. Diagnostic and therapeutic strategies based on metabolism characteristics of TME;
4. The way of metabolism reprogramming to regulate immunotherapy (ICBs, CAR-T, etc.);
5. Novel cancer metabolism therapy targets mining from big data by interdisciplinary strategies.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
