Microbiota, including viruses, bacteria, fungi, actinomyces, rickettsia, mycoplasma, chlamydia and spirochaete, pose a great threat to reproductive health. Reproductive tract infection has become a major public health issue all over the world for its high and growing prevalence, which often goes unnoticed and hence remains underdiagnosed and untreated, resulting in devastating general health effects on women and men. Infection of the female reproductive tract by pathogenic microorganisms could lead to infertility, adverse pregnancy outcomes such as spontaneous abortion and congenital diseases, and increase the risk of cancer. Meanwhile, pathogenic microorganism infection of the male reproductive tract could cause infertility and prostatitis. Especially, viral infections such as herpes simplex virus 2 (HSV-2), human immunodeficiency virus (HIV) and so on are incurable so far, which increases the risk of persistent sexual transmission. Regrettably, there is no vaccine for AIDS and HSV-2. Thus, there is an urgent need for developing vaccines to prevent the virus from infecting the reproductive tract.
This Research Topic aims to understand molecular mechanisms of reproductive system-microbiota interactions during infection and facilitate knowledge in the field of microbiology and reproductive biology, which lays the foundation for diagnosis and treatment.
We welcome submissions of Original Research, Methods, Review, Mini-Review, Hypothesis and Theory, Perspective, Case Report and Brief Research Report on the sub-topics below:
• Molecular mechanisms underlying reproductive system-microbiota interactions during infections
• The bidirectional relationship between the reproductive tract microbiota and systemic diseases
• Detecting and assessing the abundance and distribution of microorganisms in the reproductive system, which could provide the reference for choosing the stage of pregnancy and childbirth method
• Development of more sensitive and sufficient technologies for detecting microorganisms in the reproductive tract
• The cellular and signaling networks in systemic diseases associated with reproductive tract microbiota dysbiosis
Microbiota, including viruses, bacteria, fungi, actinomyces, rickettsia, mycoplasma, chlamydia and spirochaete, pose a great threat to reproductive health. Reproductive tract infection has become a major public health issue all over the world for its high and growing prevalence, which often goes unnoticed and hence remains underdiagnosed and untreated, resulting in devastating general health effects on women and men. Infection of the female reproductive tract by pathogenic microorganisms could lead to infertility, adverse pregnancy outcomes such as spontaneous abortion and congenital diseases, and increase the risk of cancer. Meanwhile, pathogenic microorganism infection of the male reproductive tract could cause infertility and prostatitis. Especially, viral infections such as herpes simplex virus 2 (HSV-2), human immunodeficiency virus (HIV) and so on are incurable so far, which increases the risk of persistent sexual transmission. Regrettably, there is no vaccine for AIDS and HSV-2. Thus, there is an urgent need for developing vaccines to prevent the virus from infecting the reproductive tract.
This Research Topic aims to understand molecular mechanisms of reproductive system-microbiota interactions during infection and facilitate knowledge in the field of microbiology and reproductive biology, which lays the foundation for diagnosis and treatment.
We welcome submissions of Original Research, Methods, Review, Mini-Review, Hypothesis and Theory, Perspective, Case Report and Brief Research Report on the sub-topics below:
• Molecular mechanisms underlying reproductive system-microbiota interactions during infections
• The bidirectional relationship between the reproductive tract microbiota and systemic diseases
• Detecting and assessing the abundance and distribution of microorganisms in the reproductive system, which could provide the reference for choosing the stage of pregnancy and childbirth method
• Development of more sensitive and sufficient technologies for detecting microorganisms in the reproductive tract
• The cellular and signaling networks in systemic diseases associated with reproductive tract microbiota dysbiosis