Acute kidney injury is a clinical syndrome characterized by a rapid loss of renal excretory function and is usually diagnosed as an accumulation of products of nitrogen metabolism such as creatinine and urea and other clinically unmeasured waste products. Infection, hypovolemic shock, medication, or invasive surgery are the main causes of AKI, and different causes of AKI have different pathophysiological mechanisms. Despite extensive investigation of AKI in experimental models, the clinical outcome of AKI has not been improved substantially in the last decade, and the therapeutic measures for AKI are still limited; no therapeutic interventions except dialysis can reliably improve the survival outcome, limit injury, or speed recovery. The long-term consequences of AKI include an increased incidence of CKD and cardiovascular disease. Therefore, the prevention and early detection of AKI are crucial.
Recent advances in the past decades have revealed the possible pathophysiological mechanisms contributing to AKI such as inflammation, mitochondrial dysfunction, oxidative stress, metabolism, and altered gut microbiota, which help to identify new targets and pathways for novel therapies. The Research Topic aims to highlight the latest advancement in basic research to tackle the potential therapeutic strategies for AKI. The Research Topic will provide an update of new developments in a wide range of novel treatment approaches from gene therapy to pharmacological intervention, which will offer guidance on future directions in the discovery and development of promising therapeutic options with the transnational potential to improve outcomes for AKI patients.
This Research Topic welcomes Original Research Articles and Reviews addressing, but not limited to, the following themes:
-Mechanism of AKI
-The relationship between urinary calculi occurrence and renal inflammation
-New biomarkers for AKI diagnosis
-Novel pharmacological targets and pathways to treat AKI
-The association between AKI and DNA genetic polymorphism
-Advanced models and technologies to study AKI, including organoid culture
-Novel treatment methods of AKI such as stem cell-based therapy, non-pharmacological interventions and personalized therapy
-Development of new drug delivery systems for AKI treatment
-Sepsis-induced AKI
Acute kidney injury is a clinical syndrome characterized by a rapid loss of renal excretory function and is usually diagnosed as an accumulation of products of nitrogen metabolism such as creatinine and urea and other clinically unmeasured waste products. Infection, hypovolemic shock, medication, or invasive surgery are the main causes of AKI, and different causes of AKI have different pathophysiological mechanisms. Despite extensive investigation of AKI in experimental models, the clinical outcome of AKI has not been improved substantially in the last decade, and the therapeutic measures for AKI are still limited; no therapeutic interventions except dialysis can reliably improve the survival outcome, limit injury, or speed recovery. The long-term consequences of AKI include an increased incidence of CKD and cardiovascular disease. Therefore, the prevention and early detection of AKI are crucial.
Recent advances in the past decades have revealed the possible pathophysiological mechanisms contributing to AKI such as inflammation, mitochondrial dysfunction, oxidative stress, metabolism, and altered gut microbiota, which help to identify new targets and pathways for novel therapies. The Research Topic aims to highlight the latest advancement in basic research to tackle the potential therapeutic strategies for AKI. The Research Topic will provide an update of new developments in a wide range of novel treatment approaches from gene therapy to pharmacological intervention, which will offer guidance on future directions in the discovery and development of promising therapeutic options with the transnational potential to improve outcomes for AKI patients.
This Research Topic welcomes Original Research Articles and Reviews addressing, but not limited to, the following themes:
-Mechanism of AKI
-The relationship between urinary calculi occurrence and renal inflammation
-New biomarkers for AKI diagnosis
-Novel pharmacological targets and pathways to treat AKI
-The association between AKI and DNA genetic polymorphism
-Advanced models and technologies to study AKI, including organoid culture
-Novel treatment methods of AKI such as stem cell-based therapy, non-pharmacological interventions and personalized therapy
-Development of new drug delivery systems for AKI treatment
-Sepsis-induced AKI