It is well established that maternal health can greatly influence her offspring’s development, leading to cardiovascular and neurological diseases later in early childhood and adulthood. However, recent studies have shown that paternal factors matter as well. One hypothesis accounting for how these factors influence the development of offspring is fetal programming, explaining that paternal environmental factors (body composition, endocrine function, nutrition, age, etc.) affect the phenotype of the offspring via epigenetic modifications.
Although great progress has been achieved in paternal fetal programming, our understanding of the detailed mechanisms is not fulfilled. This Research Topic aims to deepen our understanding in this field. We especially welcome studies using animal models or other experimental models, exploring epigenetic modifications during spermatogenesis and embryonic development periods.
This Research Topic welcomes submissions that include but are not limited to the following:
• the influence of paternal fetal programming on embryonic development, organic development, fetal development, postnatal development, fetal and offspring diseases;
• research of methylation, especially the role of the sperm whole genomic methylation or specific genes methylation;
• exploration of non-coding RNA, especially the role of the sperm microRNA, tsRNA and others;
• identification of histone acetylation, especially the role of the sperm histone acetylation.
It is well established that maternal health can greatly influence her offspring’s development, leading to cardiovascular and neurological diseases later in early childhood and adulthood. However, recent studies have shown that paternal factors matter as well. One hypothesis accounting for how these factors influence the development of offspring is fetal programming, explaining that paternal environmental factors (body composition, endocrine function, nutrition, age, etc.) affect the phenotype of the offspring via epigenetic modifications.
Although great progress has been achieved in paternal fetal programming, our understanding of the detailed mechanisms is not fulfilled. This Research Topic aims to deepen our understanding in this field. We especially welcome studies using animal models or other experimental models, exploring epigenetic modifications during spermatogenesis and embryonic development periods.
This Research Topic welcomes submissions that include but are not limited to the following:
• the influence of paternal fetal programming on embryonic development, organic development, fetal development, postnatal development, fetal and offspring diseases;
• research of methylation, especially the role of the sperm whole genomic methylation or specific genes methylation;
• exploration of non-coding RNA, especially the role of the sperm microRNA, tsRNA and others;
• identification of histone acetylation, especially the role of the sperm histone acetylation.