Apoptotic Cell Clearance in Health and Disease

246.9K

views

125

authors

25

articles

Editorial

02 October 2018

Editorial: Apoptotic Cell Clearance in Health and Disease

Estee Kurant

,

Amiram Ariel

and

Kirsten Lauber

3,750 views

2 citations

Editors

3

University of Haifa

Ludwig Maximilian University of Munich

University of Haifa

Impact

Fetching...

About

The clearance of apoptotic cells is essential for proper development, homeostasis and the termination of immune responses in multicellular organisms. Thus, the cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, the phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells that suggest it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This Research Topic issue will cover a wide range of subjects in apoptotic cell clearance:
1. Apoptotic cell clearance in embryonic development and tissue morphogenesis.
2. Apoptotic cell clearance in the maintenance of homeostatic physiology.
3. Apoptotic cell clearance in inflammation, developmental immunology and autoimmunity.
4. Apoptotic cell clearance in pathologies.
5. Molecular pathways involved in apoptotic cell clearance and related processes.

Particular focus will be given to the modulation of phagocyte/macrophage phenotype and function by apoptotic cells and the signaling cascades that govern these changes.

The clearance of apoptotic cells is essential for proper development, homeostasis and the termination of immune responses in multicellular organisms. Thus, the cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, the phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells that suggest it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This Research Topic issue will cover a wide range of subjects in apoptotic cell clearance:
1. Apoptotic cell clearance in embryonic development and tissue morphogenesis.
2. Apoptotic cell clearance in the maintenance of homeostatic physiology.
3. Apoptotic cell clearance in inflammation, developmental immunology and autoimmunity.
4. Apoptotic cell clearance in pathologies.
5. Molecular pathways involved in apoptotic cell clearance and related processes.

Particular focus will be given to the modulation of phagocyte/macrophage phenotype and function by apoptotic cells and the signaling cascades that govern these changes.

Download ebook

Share

Editors

University of Haifa

Ludwig Maximilian University of Munich

University of Haifa

Impact

246,928 Total views

179,165 Article views

63,637 Article downloads

4,126 Topic views

Published In

Journal Thumbnail

Frontiers in Immunology

Molecular Innate Immunity

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic