Over the years, the significant role of the gut microbiota in maintaining host health has attracted much attention. It has been well demonstrated that complex gut microbiota-host interactions greatly influence host homeostasis, which is associated with the development of human gastrointestinal diseases such as intestinal inflammatory diseases. Recently, strong evidence has also shown that host-microbe interactions reach far beyond the local environment. Alterations of the gut microbiota may similarly affect peripheral tissues, involving the regulation of physiology and metabolism, the balance of immunology, and the prediction and treatment of diseases. Inter-organ communication is essential for maintaining host homeostasis and disease evolution. The crosstalk between the gut microbiota and the lung has reinforced the existence of a gut–lung axis and highlighted the contribution of microbiota at both respiratory and digestive levels. The perturbation in microbial composition and function is linked to increased susceptibility to respiratory infections and other diseases. It would be of interest to further investigate the specific role of the gut microbiome in gut-lung axis-related respiratory infectious diseases.
In this Research Topic, we focus on novel insights into the intricate relationships between the gut microbiota and gut-lung axis-related diseases, as well as the potential of gut microbiota-based therapies. Original Research and Review articles that focus on, but are not limited to the following subjects are highly welcome.
1. Influence of the gut microbiota on respiratory infections (bacteria, viruses, or fungi)
2. The development of gut microbiota-based therapies for gut-lung axis-related respiratory infectious diseases
3. Meta-analyses of randomized controlled trials or primary clinical studies to assess the effectiveness of gut microbiome-based therapeutics.
4. Immune modulation of the respiratory tract by the gut microbiota and the molecular mechanism.
Over the years, the significant role of the gut microbiota in maintaining host health has attracted much attention. It has been well demonstrated that complex gut microbiota-host interactions greatly influence host homeostasis, which is associated with the development of human gastrointestinal diseases such as intestinal inflammatory diseases. Recently, strong evidence has also shown that host-microbe interactions reach far beyond the local environment. Alterations of the gut microbiota may similarly affect peripheral tissues, involving the regulation of physiology and metabolism, the balance of immunology, and the prediction and treatment of diseases. Inter-organ communication is essential for maintaining host homeostasis and disease evolution. The crosstalk between the gut microbiota and the lung has reinforced the existence of a gut–lung axis and highlighted the contribution of microbiota at both respiratory and digestive levels. The perturbation in microbial composition and function is linked to increased susceptibility to respiratory infections and other diseases. It would be of interest to further investigate the specific role of the gut microbiome in gut-lung axis-related respiratory infectious diseases.
In this Research Topic, we focus on novel insights into the intricate relationships between the gut microbiota and gut-lung axis-related diseases, as well as the potential of gut microbiota-based therapies. Original Research and Review articles that focus on, but are not limited to the following subjects are highly welcome.
1. Influence of the gut microbiota on respiratory infections (bacteria, viruses, or fungi)
2. The development of gut microbiota-based therapies for gut-lung axis-related respiratory infectious diseases
3. Meta-analyses of randomized controlled trials or primary clinical studies to assess the effectiveness of gut microbiome-based therapeutics.
4. Immune modulation of the respiratory tract by the gut microbiota and the molecular mechanism.
