About this Research Topic
The alteration of metabolic mode is a distinct characteristic for abnormal activation of immune cell-mediated diseases, which provides the necessary energy and macromolecular substances for rapid activation and growth of cells in a short time, involving three metabolisms of glucose, fat, and amino acids. For example, in general, normal or differentiated cells mainly rely on oxidative phosphorylation of mitochondria to provide energy under aerobic conditions, while rapidly proliferating cells rely on glycolysis to provide energy even under sufficient oxygen supply. This alteration in metabolic mode can not only provide energy in a short time but also provide carbon or nitrogen sources for the synthesis of macromolecules.
Immunological skin diseases are complex and diverse and difficult to prevent and treat. According to the rough estimate of the global disease burden study, the loss of healthy life caused by subcutaneous diseases ranks third among all diseases. Immunological skin diseases such as urticarial, atopic dermatitis, and psoriasis are thought to be caused by various activated immune cells including Th cells, mast cells, antigen-presenting cells (dendritic cells and macrophages), IgE-producing plasma cells, eosinophils, basophils, and innate lymphocyte type II cells (ILC2s). Those immune cells perform their effector function, such as activation, differentiation, proliferation, migration, etc., which are believed to require metabolic alteration. Therefore, studying the role of metabolism in immunological skin diseases will reveal the features of metabolic abnormalities in skin diseases, identify the novel mechanism of action, and form novel treatment strategies.
The goal of this Research Topic is to investigate new metabolic and immune mechanisms in immunological skin diseases, clarify novel characteristics of immune cell metabolism, identify potential targets for future treatment, and provide new treatment strategies for immunological skin diseases.
In the topic of metabolism and immune mechanisms of immunological skin diseases, diseases could include urticaria, atopic dermatitis, psoriasis, allergic contact dermatitis, etc. The research points that need to be addressed by contributors are as follows:
1) Metabolic mechanisms related to the activation of immune cells (such as Th cells, dendritic cells, mast cells, macrophages, basophils, and ILCs) which are involved in inducing and maintaining immune responses;
2) Identify new target molecules and new strategies for treating immunological skin diseases;
3) Novel diagnostic markers developed for metabolic and immune characteristics of skin diseases.
Immunological skin diseases are complex and diverse and difficult to prevent and treat. According to the rough estimate of the global disease burden study, the loss of healthy life caused by subcutaneous diseases ranks third among all diseases. Immunological skin diseases such as urticarial, atopic dermatitis, and psoriasis are thought to be caused by various activated immune cells including Th cells, mast cells, antigen-presenting cells (dendritic cells and macrophages), IgE-producing plasma cells, eosinophils, basophils, and innate lymphocyte type II cells (ILC2s). Those immune cells perform their effector function, such as activation, differentiation, proliferation, migration, etc., which are believed to require metabolic alteration. Therefore, studying the role of metabolism in immunological skin diseases will reveal the features of metabolic abnormalities in skin diseases, identify the novel mechanism of action, and form novel treatment strategies.
The goal of this Research Topic is to investigate new metabolic and immune mechanisms in immunological skin diseases, clarify novel characteristics of immune cell metabolism, identify potential targets for future treatment, and provide new treatment strategies for immunological skin diseases.
In the topic of metabolism and immune mechanisms of immunological skin diseases, diseases could include urticaria, atopic dermatitis, psoriasis, allergic contact dermatitis, etc. The research points that need to be addressed by contributors are as follows:
1) Metabolic mechanisms related to the activation of immune cells (such as Th cells, dendritic cells, mast cells, macrophages, basophils, and ILCs) which are involved in inducing and maintaining immune responses;
2) Identify new target molecules and new strategies for treating immunological skin diseases;
3) Novel diagnostic markers developed for metabolic and immune characteristics of skin diseases.
Keywords: Metabolism, Immunological Skin Diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
