Internal and External Factors affecting Polycystic Ovary Syndrome

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Background

Polycystic ovary syndrome (PCOS) pathophysiology is modified by a multitude of internal and external factors that go far beyond the traditional stimulators and inhibitors of endocrine response and function. This research topic specifically welcomes new and novel data that extends our knowledge about how PCOS is modulated by these factors. This could include both the internal modulators of physiological function, including the application of “omics” to PCOS, or external endocrine modulators, including those of the endocrine disruptor chemicals. This research topic also welcomes review articles that provide an in-depth summary and analysis of the currently available literature in an area of relevance to this disorder. The Research Topic aims to achieve a deeper understanding of the effects of internal and external factors that impact upon the disease process in polycystic ovary syndrome (PCOS). To achieve this, we encourage the application of state-of-the-art methodologies such as ‘omics to be applied to PCOS to enable a mechanistic understanding of the disease process. We would also seek to understand the impact of a spectrum of endocrine disrupting chemicals, as measured by sensitive state-of-the-art methodologies, upon the endocrine functions of women with PCOS. A further aim is to attract high quality review articles that summarize, explain and critically analyze current knowledge in the area for the purpose of synthesizing current knowledge and guiding future research.

This Research Topic is interested in original research articles that offer novel insights into the disease process of polycystic ovary syndrome (PCOS) as well as review articles that summarize the current literature and offer insights into the pathophysiology of the disease process in PCOS.

- Studies involving state-of-the-art ‘omics approaches are particularly encouraged, especially where they bring mechanistic insight to a facet of the pathophysiology of PCOS.

- The range of ‘omic analysis is encouraged: proteomics, metabolomics, genomics, and transcriptomics.

- Longitudinal studies of women with PCOS will be of particular value.

- Human and in vivo animal studies are welcomed, as well as in vitro cell models of PCOS.

- Studies that include determination of endocrine disrupting chemicals (EDCs) in PCOS are encouraged.

Keywords: Polycystic ovary syndrome; hyperandrogenism; obesity; metabolic syndrome; endocrine disruptors

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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