The skin provides physical and immunological barriers to protect the organism from pathogens and physical dangers while maintaining tissue homeostasis. Dysregulation of the protective machinery consequently leads to the initiation and progression of inflammatory pathways in the epithelial microenvironment, inducing inflammatory skin diseases (such as atopic dermatitis and psoriasis). The inflammatory events mainly occur in the epithelial immune microenvironment (EIME), i.e., the location of the epidermis and papillary dermis that are 0.1–0.2 mm beneath the skin surface. The microbiota and peripheral nerves also contribute to the EIME. EIMEs represent a new therapeutic target for the treatment of inflammatory skin diseases by regulating the inflammatory loops. Unraveling disease-specific EIMEs facilitates the development of new therapies for inflammatory skin diseases.
This Research Topic provides a forum to explore the relationship between the epithelial immune microenvironment and inflammatory skin diseases. The goal is to improve the treatment of inflammatory skin disease by regulating the epithelial immune microenvironment.
Original Research, Reviews, and Perspective articles are welcome in the special issue. The topics may cover, but are not limited to, the following issues:
1. The inflammatory loop in inflammatory skin diseases.
2. Regulatory mechanisms of the epithelial immune microenvironment in the pathogenesis of inflammatory skin diseases.
3. Potential targets and drugs for intervention in the epithelial immune microenvironment to treat inflammatory skin diseases.
4. Crosstalk between the microbiome and the epithelial immune microenvironment to affect inflammatory skin disease.
5. Role of epigenetic changes in various cell types in inflammatory skin diseases.
6. Development of drug delivery systems to regulate the epithelial immune microenvironment.
The skin provides physical and immunological barriers to protect the organism from pathogens and physical dangers while maintaining tissue homeostasis. Dysregulation of the protective machinery consequently leads to the initiation and progression of inflammatory pathways in the epithelial microenvironment, inducing inflammatory skin diseases (such as atopic dermatitis and psoriasis). The inflammatory events mainly occur in the epithelial immune microenvironment (EIME), i.e., the location of the epidermis and papillary dermis that are 0.1–0.2 mm beneath the skin surface. The microbiota and peripheral nerves also contribute to the EIME. EIMEs represent a new therapeutic target for the treatment of inflammatory skin diseases by regulating the inflammatory loops. Unraveling disease-specific EIMEs facilitates the development of new therapies for inflammatory skin diseases.
This Research Topic provides a forum to explore the relationship between the epithelial immune microenvironment and inflammatory skin diseases. The goal is to improve the treatment of inflammatory skin disease by regulating the epithelial immune microenvironment.
Original Research, Reviews, and Perspective articles are welcome in the special issue. The topics may cover, but are not limited to, the following issues:
1. The inflammatory loop in inflammatory skin diseases.
2. Regulatory mechanisms of the epithelial immune microenvironment in the pathogenesis of inflammatory skin diseases.
3. Potential targets and drugs for intervention in the epithelial immune microenvironment to treat inflammatory skin diseases.
4. Crosstalk between the microbiome and the epithelial immune microenvironment to affect inflammatory skin disease.
5. Role of epigenetic changes in various cell types in inflammatory skin diseases.
6. Development of drug delivery systems to regulate the epithelial immune microenvironment.