Cancer and the human body are inextricably linked and continually interacting. Tumors can have an impact on the human body by producing cell signaling chemicals that shape their favorable microenvironment, influence metabolism, modulate microbiota composition, and promote immunological tolerance. On the other hand, exogenous and colonizing microbes, metabolites of the body, and microenvironment can influence cancer cell growth and development.
Few microorganisms cause cancer directly, but many appear to be complicit in cancer growth, frequently operating through the host's microenvironment. The gut ecosystem has the potential to influence cancer by influencing inflammatory and metabolic processes. Furthermore, intra-tumor microorganisms have been shown to have particular impacts on tumors via reprogramming the microenvironment. Cancer cells and microorganisms can modify their metabolism in reaction to their microenvironment, giving them a selective advantage in evading the immune response, surviving, proliferating, and metastasizing. Meanwhile, altered tumor metabolism has emerged as one of the most promising aspects of cancer therapy, which offers specific targeting of cancer cells and activates immune responses. The tumor microenvironment (TME) includes surrounding blood vessels, immune cells, fibroblasts, microorganisms, various signaling molecules, and extracellular matrix. The acellular components of TME can mediate drug resistance by building physical barriers, affecting tumor cell growth and metabolism.
This topic advocates the importance of microorganisms (virus, bacterial and fungal), metabolism, and microenvironment in cancer and cancer treatment. Studying the dynamic relationship between tumor surroundings and microbes, and clarifying the molecular mechanism of Metabolism factors referring to TME in the process of tumor progression, are the key elements of cancer prevention and treatment. The aim of this topic is committed to provide high-quality, latest and advanced research, review and commentary articles in microbes, Metabolism, Microenvironment and Cancer through various methods, including sequencing, bioassay, experimental models and organoids. We hope to understand the impact of the balance between the body's endogenous environment and cancer, develop novel targeted therapeutic strategies, and provide more markers for cancer prediction, diagnosis, and prognosis.
All manuscript types including original research articles of both basic and clinical studies and reviews are welcome, but not limited to, the following:
• Mechanisms of microbe, metabolism, and microenvironment involvement in cancer origination and development.
• Signaling pathways involved in metabolism, inflammation, and ecosystem in the tumor microenvironment.
• Bioinformatics or big data demonstrating the role of the microbe, metabolism, and microenvironment in cancer.
• Molecular therapeutic mechanisms and clinical studies related to cancer microbiology, metabolology, and Immunology.
• Biomarkers and therapeutic targets related to microbe, metabolism, and microenvironment.
• Drug resistance mechanism related to microbe, metabolism, and microenvironment.
Please Note:
1. Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in Frontiers in Genetics.
2. Clinical Trial articles will be accepted for review only if they are randomized, double-blinded, and placebo controlled. Statistical power analysis or a justification of the sample size is mandatory.
Cancer and the human body are inextricably linked and continually interacting. Tumors can have an impact on the human body by producing cell signaling chemicals that shape their favorable microenvironment, influence metabolism, modulate microbiota composition, and promote immunological tolerance. On the other hand, exogenous and colonizing microbes, metabolites of the body, and microenvironment can influence cancer cell growth and development.
Few microorganisms cause cancer directly, but many appear to be complicit in cancer growth, frequently operating through the host's microenvironment. The gut ecosystem has the potential to influence cancer by influencing inflammatory and metabolic processes. Furthermore, intra-tumor microorganisms have been shown to have particular impacts on tumors via reprogramming the microenvironment. Cancer cells and microorganisms can modify their metabolism in reaction to their microenvironment, giving them a selective advantage in evading the immune response, surviving, proliferating, and metastasizing. Meanwhile, altered tumor metabolism has emerged as one of the most promising aspects of cancer therapy, which offers specific targeting of cancer cells and activates immune responses. The tumor microenvironment (TME) includes surrounding blood vessels, immune cells, fibroblasts, microorganisms, various signaling molecules, and extracellular matrix. The acellular components of TME can mediate drug resistance by building physical barriers, affecting tumor cell growth and metabolism.
This topic advocates the importance of microorganisms (virus, bacterial and fungal), metabolism, and microenvironment in cancer and cancer treatment. Studying the dynamic relationship between tumor surroundings and microbes, and clarifying the molecular mechanism of Metabolism factors referring to TME in the process of tumor progression, are the key elements of cancer prevention and treatment. The aim of this topic is committed to provide high-quality, latest and advanced research, review and commentary articles in microbes, Metabolism, Microenvironment and Cancer through various methods, including sequencing, bioassay, experimental models and organoids. We hope to understand the impact of the balance between the body's endogenous environment and cancer, develop novel targeted therapeutic strategies, and provide more markers for cancer prediction, diagnosis, and prognosis.
All manuscript types including original research articles of both basic and clinical studies and reviews are welcome, but not limited to, the following:
• Mechanisms of microbe, metabolism, and microenvironment involvement in cancer origination and development.
• Signaling pathways involved in metabolism, inflammation, and ecosystem in the tumor microenvironment.
• Bioinformatics or big data demonstrating the role of the microbe, metabolism, and microenvironment in cancer.
• Molecular therapeutic mechanisms and clinical studies related to cancer microbiology, metabolology, and Immunology.
• Biomarkers and therapeutic targets related to microbe, metabolism, and microenvironment.
• Drug resistance mechanism related to microbe, metabolism, and microenvironment.
Please Note:
1. Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in Frontiers in Genetics.
2. Clinical Trial articles will be accepted for review only if they are randomized, double-blinded, and placebo controlled. Statistical power analysis or a justification of the sample size is mandatory.