Unraveling Enteroviral Pathogenesis: Host Interactions and Antiviral Strategies in Asia

8.9K

views

44

authors

5

articles

Editorial

13 December 2024

Editorial: Unraveling enteroviral pathogenesis: host interactions and antiviral strategies in Asia

Hung-Yao Ho

356 views

0 citations

Editors

2

Fudan University

Chang Gung University

Impact

Original Research

11 January 2024

Assessing the impact of COVID-19 interventions on the hand, foot and mouth disease in Guangdong Province, China: a Bayesian modeling study

Li Zhang

, 19 more and

Meng Zhang

Background: The non-pharmaceutical interventions (NPIs) against COVID-19 may have affected the transmission of hand, foot and mouth disease (HFMD). We aimed to assess the impact of the NPIs on HFMD in the high epidemic area of HFMD, Guangdong Province.

Methods: The data of HFMD cases, etiological information, and meteorological factors in Guangdong from January 1, 2012, to December 31, 2021, were collected. Using a Bayesian structural time series (BSTS) model integrated counterfactual framework, we assessed the effect of NPIs on HFMD by different intervention periods, populations (gender, age, occupation), and cities. We further explored the correlation between the reduction of HFMD and socioeconomic factors in 21 cities.

Results: A total of 351,217 HFMD cases were reported and 455,327 cases were averted in Guangdong Province during 2020–2021 with a reduction of 84.94% (95%CI: 81.63–87.22%) in 2020 and 29.49% (95%CI: 15.26–39.54%) in 2021. The impact of NPIs on HFMD differed by age and gender. The effects of NPIs were more remarkable for children aged 0–2 years and scattered children. We found that the relative reductions in 21 cities were related to the composition ratio of children and COVID-19 incidence.

Conclusion: The reduction of HFMD incidence was significantly associated with COVID-19 NPIs, and school closure was an effective intervention to prevent HFMD outbreaks. Our findings will contribute to the development of HFMD prevention and control measures.

2,011 views

6 citations

Monthly incidence of HFMD in mainland China from 2014 to 2017. (A) Monthly incidence of HFMD in 7 provinces located on the southern and eastern coasts of mainland China. (B) Monthly incidence of HFMD in 12 provinces located in central and south-western mainland China. (C) Monthly incidence of HFMD in 12 provinces located in western and northern mainland China.

Original Research

26 January 2024

Spatiotemporal patterns and risk mapping of provincial hand, foot, and mouth disease in mainland China, 2014–2017

Yuxin Wei

, 4 more and

Tiejun Shui

2,332 views

3 citations

Original Research

01 May 2024

Epidemiological and etiological investigations of hand, foot, and mouth disease in Jiashan, northeastern Zhejiang Province, China, during 2016 to 2022

Yongjuan Yuan

, 5 more and

Haiyan Mao

2,024 views

2 citations

Original Research

19 November 2024

Trend of hand, foot and mouth disease before, during, and after China’s COVID control policies in Zhejiang, China

Zheyuan Ding

, 7 more and

Queping Song

1,607 views

0 citations

Open for submission

Frontiers in Virology

SARS-CoV-2: Virology, Epidemiology, Diagnosis, Pathogenesis and Control, Volume II

Edited by Severino Jefferson Ribeiro Da Silva, Zhen Qin, Ronaldo Celerino Da Silva, Larissa Krokovsky

Deadline

21 August 2025

Recommended Research Topics

Frontiers in Virology

Translational Virology in Pregnancy

Edited by Kristina M Adams Waldorf, Vikki M Abrahams

51.9K

views

76

authors

12

articles

Frontiers in Microbiology

Influence of Protein-Protein Interactions (PPIs) on the outcome of viral infections

Edited by Gorka Lasso Cabrera, Pablo Guardado-Calvo, Rohit K Jangra, Eva Mittler, Mercè Llabrés

47.3K

views

60

authors

10

articles

Frontiers in Microbiology

Emerging and Re-emerging Viral Diseases

Edited by Shuofeng Yuan, Xing-Yi Ge, Xin Yin, Jun Wang

541.2K

views

360

authors

37

articles

Frontiers in Microbiology

The Interaction between Host and Viruses causing Respiratory or Gastrointestinal Tract Infections in Humans

Edited by Wenjun Song, Sook-San Wong, Mark Zanin

16.5K

views

18

authors

3

articles

Frontiers in Virology

SARS-CoV-2: Virology, Epidemiology, Diagnosis, Pathogenesis, and Control

Edited by Severino Jefferson Ribeiro Da Silva, Sachin Kumar, LINDOMAR JOSE PENA, Severino Jefferson Ribeiro da Silva

59.2K

views

339

authors

24

articles

About

Enteroviruses are pathogens that can cause a range of human diseases, and the genus Enterovirus consists of 15 species, including Enterovirus A-L and Rhinovirus A-C. Notably, Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are significant infectious agents responsible for hand, foot, and mouth disease (HFMD), which can lead to severe neural complications. The majority of HFMD outbreaks have been reported in the Asia-Pacific region, including countries such as Malaysia, Vietnam, China, and India. Despite the implementation of vaccination and public health interventions, enteroviruses continue to circulate in this region. A critical gap in the current state of knowledge is the lack of specific antiviral drugs against EV-A71, with clinical treatment remaining largely supportive. Understanding the host-enterovirus relationship and the underlying pathogenic mechanisms is crucial for elucidating the viral pathogenesis of RNA viruses. Additionally, other enteroviruses, such as Enterovirus D68 (EV-D68), have caused significant outbreaks and are associated with severe respiratory symptoms and acute flaccid myelitis in children. This highlights the need for a deeper investigation into the molecular mechanisms of enteroviral infections and the development of effective therapeutic strategies.

This research topic aims to explore the molecular mechanisms of viral pathogenesis, identify host factors involved in enteroviral infections, and develop new detection methods and antiviral therapies for enteroviruses. By addressing these objectives, the research seeks to answer critical questions about the host-pathogen interactions and the development of effective treatments for enteroviral diseases.

To gather further insights into the host-enterovirus relationship and the pathogenic mechanisms of enteroviruses, we welcome articles addressing, but not limited to, the following themes:

- Molecular mechanisms of enteroviral pathogenesis
- Host factors involved in enteroviral infections
- Development of new detection methods for enteroviruses
- Advances in antiviral therapies for enteroviruses
- Epidemiological studies of enteroviral outbreaks in the Asia-Pacific region
- Clinical management and treatment strategies for enteroviral infections
- Comparative studies of different enterovirus species and their pathogenicity

Enteroviruses are pathogens that can cause a range of human diseases, and the genus Enterovirus consists of 15 species, including Enterovirus A-L and Rhinovirus A-C. Notably, Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are significant infectious agents responsible for hand, foot, and mouth disease (HFMD), which can lead to severe neural complications. The majority of HFMD outbreaks have been reported in the Asia-Pacific region, including countries such as Malaysia, Vietnam, China, and India. Despite the implementation of vaccination and public health interventions, enteroviruses continue to circulate in this region. A critical gap in the current state of knowledge is the lack of specific antiviral drugs against EV-A71, with clinical treatment remaining largely supportive. Understanding the host-enterovirus relationship and the underlying pathogenic mechanisms is crucial for elucidating the viral pathogenesis of RNA viruses. Additionally, other enteroviruses, such as Enterovirus D68 (EV-D68), have caused significant outbreaks and are associated with severe respiratory symptoms and acute flaccid myelitis in children. This highlights the need for a deeper investigation into the molecular mechanisms of enteroviral infections and the development of effective therapeutic strategies.

This research topic aims to explore the molecular mechanisms of viral pathogenesis, identify host factors involved in enteroviral infections, and develop new detection methods and antiviral therapies for enteroviruses. By addressing these objectives, the research seeks to answer critical questions about the host-pathogen interactions and the development of effective treatments for enteroviral diseases.

To gather further insights into the host-enterovirus relationship and the pathogenic mechanisms of enteroviruses, we welcome articles addressing, but not limited to, the following themes:

- Molecular mechanisms of enteroviral pathogenesis
- Host factors involved in enteroviral infections
- Development of new detection methods for enteroviruses
- Advances in antiviral therapies for enteroviruses
- Epidemiological studies of enteroviral outbreaks in the Asia-Pacific region
- Clinical management and treatment strategies for enteroviral infections
- Comparative studies of different enterovirus species and their pathogenicity

Share

Editors

Fudan University

Chang Gung University

Impact

8,912 Total views

5,574 Article views

2,398 Article downloads

940 Topic views

Published In

Journal Thumbnail

Frontiers in Virology

Emerging and Reemerging Viruses

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic